Apolipoprotein E genotype and sex influence C-reactive protein levels regardless of exercise training status

    Authors

    T. J. Angelopoulos; M. P. Miles; J. Lowndes; S. A. Sivo; R. L. Seip; L. S. Pescatello; R. F. Zoeller; P. S. Visich; P. M. Gordon; N. M. Moyna;P. D. Thompson

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    Abbreviated Journal Title

    Metab.-Clin. Exp.

    Keywords

    OBESE POSTMENOPAUSAL WOMEN; E EPSILON-4 ALLELE; MIDDLE-AGED MEN; E; POLYMORPHISM; WEIGHT-LOSS; PLASMA-LEVELS; CARDIORESPIRATORY FITNESS; INFLAMMATORY RESPONSE; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; Endocrinology & Metabolism

    Abstract

    C-reactive protein (CRP) is a marker for systemic inflammation and increased cardiovascular disease risk. Regular exercise may decrease CRP. Apolipoprotein E (apo E) has 3 common genotype variants-E2/3, 3/3, and 3/4-that modulate lipid metabolism and may have other metabolic physiologic roles, including some evidence that the genotype affects CRP levels. We assessed fasting serum CRP in 117 (male = 5 1, female = 66) healthy adults who Volunteered for a 6-month aerobic exercise program. Both pre- and posttraining measurements were available in 71 (male = 3 1, female = 40) subjects. At baseline and follow-up, the numbers of subjects in the 3 groups were approximately equal: 2/3, n = 33 and 20; 3/3, n = 41 and 26; and 3/4, n = 43 and 25. At baseline, CRP levels differed by apo E genotype: means +/- SD were 2.84 +/- 2.18, 2.59 +/- 2.34, and 1.90 +/- 2.13 mg/L for E2/3, 3/3, and 3/4 subjects, respectively (3/4 vs 2/3, P < .05). In women, CRP was higher than that in men (3.14 +/- 2.49 vs 2.12 +/- 2.13 mg/L, P < .006). Exercise failed to affect CRP in the entire cohort (2.68 +/- 2.38 vs 2.52 +/- 2.48 mg/L) or in any apo E genotype group, and the apo E genotype effect observed at baseline persisted after training. In a largely white study cohort, CRP is higher in apo E3/3 than in 3/4 subjects and in women compared with men, but remains unchanged by 6 months of standard aerobic exercise training of the volume and higher intensity promoted by national organizations to reduce cardiovascular disease risk. How apo E genotype affects CRP is not known. (c) 2008 Elsevier Inc. All rights reserved.

    Journal Title

    Metabolism-Clinical and Experimental

    Volume

    57

    Issue/Number

    9

    Publication Date

    1-1-2008

    Document Type

    Article

    Language

    English

    First Page

    1204

    Last Page

    1210

    WOS Identifier

    WOS:000259177100006

    ISSN

    0026-0495

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