Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women

    Authors

    E. E. Pistilli; H. Gordish-Dressman; R. L. Seip; J. M. Devaney; P. D. Thompson; T. B. Price; T. J. Angelopoulos; P. M. Clarkson; N. M. Moyna; L. S. Pescatello; P. S. Visich; R. F. Zoeller; E. P. Hoffman;P. M. Gordon

    Comments

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    Abbreviated Journal Title

    Obesity

    Keywords

    adipokines; resistin; polymorphisms; muscle; exercise; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; GENE POLYMORPHISM; OBESITY; PROMOTER; GLUCOSE; HUMANS; LEPTIN; ADIPONECTIN; METABOLISM; Endocrinology & Metabolism; Nutrition & Dietetics

    Abstract

    Objective: The biological function of resistin (RST) is unknown, although it may have roles in obesity, diabetes, and insulin resistance. The objective of this study was to examine the effects of single nucleotide polymorphisms (SNPs) in the human RST gene on muscle, bone, and adipose tissue phenotypes and in response to resistance training (RT). Research Methods and Procedures: Subjects were white and consisted of strength (n = 482) and size (n = 409) cohorts who had not performed RT in the previous year. Subjects completed 12 weeks of structured, unilateral upper arm RT aimed at increasing the size and strength of the non-dominant arm, using their dominant arm as an untrained control. Strength measurements were taken pre-and post-12-week RT and consisted of elbow flexor isometric strength and one-repetition maximum during a biceps curl using free weights. Whole muscle, subcutaneous fat, and cortical bone volumes were measured by magnetic resonance imaging. Six RST SNPs were identified. Analysis of covariance was used to test for effects of the SNPs on pre- and post-muscle strength and whole muscle, fat, and bone volumes independent of gender, age, and body weight. Results: Five RST SNPs (-537 A > C, -420 C > G, 398 C > T, 540 G > A, 980 C > G) were associated with measured phenotypes among subjects when stratified by BMI ( < 25, > = 25 kg/m(2)). Several gender-specific associations were observed between RST SNPs and phenotypes among individuals with a BMI >= 25. Conversely, only two associations were observed among individuals with a BMI < 25. Discussion: These data support previous identified associations of RST with adipose tissue and demonstrate additional associations with bone and skeletal muscle that warrant further investigation.

    Journal Title

    Obesity

    Volume

    15

    Issue/Number

    2

    Publication Date

    1-1-2007

    Document Type

    Article

    Language

    English

    First Page

    392

    Last Page

    402

    WOS Identifier

    WOS:000249605600016

    ISSN

    1930-7381

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