Gd nanoparticulates: from magnetic resonance imaging to neutron capture therapy

    Authors

    P. Sharma; S. C. Brown; G. Walter; S. Santra; E. Scott; H. Ichikawa; Y. Fukumori;B. M. Moudgil

    Comments

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    Abbreviated Journal Title

    Adv. Powder Technol.

    Keywords

    gadolinium; nanoparticles; magnetic resonance imaging; neutron capture; therapy; cancer; liposomes; emulsions; dendrimer; MRI CONTRAST AGENTS; SOLID LIPID NANOPARTICLES; GADOLINIUM-LABELED; LIPOSOMES; SENSITIVE PARAMAGNETIC LIPOSOMES; POLYAMIDOAMINE DENDRIMER; CORE; CONTROLLED DRUG-DELIVERY; TUMOR-BEARING MICE; INTRAVENOUS; PERFLUBRON EMULSION; STERICALLY STABILIZED LIPOSOMES; DROPLET; COALESCENCE TECHNIQUE; Engineering, Chemical

    Abstract

    Gadolinium (Gd) chelates have been extensively applied to enhance the imagery of anatomical tissues via magnetic resonance imaging (MRI). These molecular complexes have become some of the most common clinically applied contrast agents in modern medicine. The expansive development and clinical application of Gd chelates for MRI applications has led to a rebirth of interest in the use of Gd as a radiosensitizer in neutron capture therapy (NCT). However, the poor selective tissue labeling and localization provided by conventional molecular Gd chelates has limited success in both MRI and NCT applications. Methods for encapsulating Gd into nanoparticulate materials have been developed to overcome these limitations. Incorporating Gd chelates into nanoparticulate materials affords additional flexibility in engineering targeting and also provides a means to apply high tissue-centric concentrations of Gd - often critical for both imaging and therapeutic applications. The focus of this review is to summarize the evolution of engineered Gd nanoparticles, from self-assembled macromolecular structures to rigid particulate systems for enhanced MRI contrast and, separately, Gd NCT therapy.

    Journal Title

    Advanced Powder Technology

    Volume

    18

    Issue/Number

    6

    Publication Date

    1-1-2007

    Document Type

    Article; Proceedings Paper

    Language

    English

    First Page

    663

    Last Page

    698

    WOS Identifier

    WOS:000251176600007

    ISSN

    0921-8831

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