Accelerated multiple-pass moving average: A novel algorithm for baseline estimation in CE and its application to baseline correction on real-time bases

    Authors

    A. Solis; M. Rex; A. D. Campiglia;P. Sojo

    Comments

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    Abbreviated Journal Title

    Electrophoresis

    Keywords

    accelerated multiple-pass moving average; CE; real-time baseline; correction; CAPILLARY-ELECTROPHORESIS; Biochemical Research Methods; Chemistry, Analytical

    Abstract

    We present a novel algorithm for baseline estimation in CE. The new algorithm which we have named as accelerated multiple-pass moving average (AMPMA) is combined to three preexisting low-pass filters, spike-removal, moving average, and multi-pass moving average filter, to achieve real-time baseline correction with commercial instrumentation. The successful performance of AMPMA is demonstrated with simulated and experimental data. Straightforward comparison of experimental data clearly shows the improvement AMPMA provides to the linear fitting, LOD, and accuracy (absolute error) of CE analysis.

    Journal Title

    Electrophoresis

    Volume

    28

    Issue/Number

    8

    Publication Date

    1-1-2007

    Document Type

    Article

    Language

    English

    First Page

    1181

    Last Page

    1188

    WOS Identifier

    WOS:000246116100003

    ISSN

    0173-0835

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