A new water-soluble near-neutral ratiometric fluorescent pH indicator

    Authors

    S. Yao; K. J. Schafer-Hales;K. D. Belfield

    Comments

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    Abbreviated Journal Title

    Org. Lett.

    Keywords

    ABSORBING FLUORENE DERIVATIVES; ASCITES TUMOR-CELLS; SERIES; CHROMOPHORES; EXCITATION; PROBES; RANGE; Chemistry, Organic

    Abstract

    Donor-pi-acceptor fluorene derivative 1c is a near-neutral pH indicator whose pK(a) of similar to 7.0 was determined by both absorption and fluorescence methods. 1c satisfies important criteria for a sensitive ratiomeric fluorescent pH indicator with a distinctive isoemissive point, good dispersion in cell cytosol, and low cytotoxicity. Furthermore, its 2PA cross section of 100 GM in its neutral form suggests its. potential in two-photon fluorescence imaging applications.

    Journal Title

    Organic Letters

    Volume

    9

    Issue/Number

    26

    Publication Date

    1-1-2007

    Document Type

    Article

    Language

    English

    First Page

    5645

    Last Page

    5648

    WOS Identifier

    WOS:000251614900079

    ISSN

    1523-7060

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