Reactive radical scavenging and xanthine oxidase inhibition of proanthocyanidins from Carallia brachiata

    Authors

    P. Phuwapraisirisan; P. Sowanthip; D. H. Miles;S. Tip-Pyang

    Comments

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    Abbreviated Journal Title

    Phytother. Res.

    Keywords

    Carallia brachiata; carallidin; antioxidant; proanthocyanidin; xanthine; oxidase; radical scavenging; CONSTITUENTS; FLAVONOIDS; Chemistry, Medicinal; Pharmacology & Pharmacy

    Abstract

    Antioxidant-guided separation of Carallia brachiata bark led to a new A-type trimeric proanthocyanidin named carallidin (1), along with mahuarmin A (2) and p-hydroxy benzoic acid (3). The structure of 1 was fully characterized by interpretation of spectroscopic data and chemical means. Compounds 1 and 2 exhibited radical scavenging against DPPH (IC50 102 and 182 mu m) and superoxide radical (IC50 1.47 and 9.74 mu m). In addition, 1 and 2 also inhibited xanthine oxidase with IC, values of 12.9 and 16.0 mu m. Copyright (c) 2006 John Wiley & Sons, Ltd.

    Journal Title

    Phytotherapy Research

    Volume

    20

    Issue/Number

    6

    Publication Date

    1-1-2006

    Document Type

    Article

    Language

    English

    First Page

    458

    Last Page

    461

    WOS Identifier

    WOS:000238370200006

    ISSN

    0951-418X

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