Surface modification of silicon and silica in biological environment: an X-ray photoelectron spectroscopy study

    Authors

    S. Seal; T. L. Barr; S. Krezoski;D. Petering

    Abbreviated Journal Title

    Appl. Surf. Sci.

    Keywords

    silicon; silica; XPS or ESCA; biocells; pathogenesis; surface analysis; TOXICITY; HEMOLYSIS; PARTICLES; CHEMISTRY; CELLS; Chemistry, Physical; Materials Science, Coatings & Films; Physics, ; Applied; Physics, Condensed Matter

    Abstract

    The Earth's crust is primarily made of various silicate materials upon which we successfully dwell everyday. Numerous biomedical studies, however, have documented the toxicity of some of these materials when interacted with biological cells. It has become apparent that the surface chemistry of these silicates plays a key role in the cell pathogenesis, thus enhancing the value of the use of electron spectroscopy for chemical analysis (ESCA) or X-ray photoelectron spectroscopy (XPS) as a key method for analysis. Recent studies suggest that many common silicates, including silica itself, may not be innocuous to cell pathogenecity, thus suggesting their inclusion in these XPS studies. This paper presents a detailed study of the surface chemical modification of silicon and silica when interacting with Ehrlich cells. XPS studies at selected stages of cell treatment reveal cell-induced alteration in the carbon, silicon, and oxygen of these silicon-based materials as well as changes in the carbon, iron, and nitrogen of the cell chemistry. Supporting results from the atomic absorption spectroscopy show similar changes. (C) 2001 Published by Elsevier Science B.V.

    Journal Title

    Applied Surface Science

    Volume

    173

    Issue/Number

    3-4

    Publication Date

    1-1-2001

    Document Type

    Article

    Language

    English

    First Page

    339

    Last Page

    351

    WOS Identifier

    WOS:000167479800020

    ISSN

    0169-4332

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