Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome

    Authors

    E. E. Pistilli; J. M. Devaney; H. Gordish-Dressman; M. K. Bradbury; R. L. Seip; P. D. Thompson; T. J. Angelopoulos; P. M. Clarkson; N. M. Moyna; L. S. Pescatello; P. S. Visich; R. F. Zoeller; P. M. Gordon;E. P. Hoffman

    Comments

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    Abbreviated Journal Title

    Cytokine

    Keywords

    polymorphisms; cytokines; metabolic syndrome; TUMOR-BEARING RATS; SKELETAL-MUSCLE; CARBOHYDRATE INGESTION; RHEUMATOID-ARTHRITIS; GENE POLYMORPHISMS; IL-2 RECEPTOR; BETA-CHAIN; T-CELLS; CYTOKINE; STRENGTH; Biochemistry & Molecular Biology; Cell Biology; Immunology

    Abstract

    The aims of this study were to examine associations between two SNPs in the human IL-15 gene and three SNPs in the IL-15R alpha gene with predictors of metabolic syndrome and phenotypes in muscle, strength, and bone at baseline and in response to resistance training (RT). Subjects were Caucasians who had not performed RT in the previous year and consisted of a strength cohort (n = 748), volumetric cohort (n = 722), and serum cohort (n = 544). Subjects completed 12 weeks of unilateral RT of the non-dominant arm, using their dominant arm as an untrained control. ANCOVA analyses revealed gender-specific associations with: (1) IL-15 SNP (rs1589241) and cholesterol (p = 0.04), LDL (p = 0.02), the homeostasis model assessment (HOMA; p = 0.03), and BMI (p = 0.002); (2) IL-15 SNP (rs 1057972) and the pre- to post-training absolute difference in 1RM strength (p = 0.02), BMI (p = 0.008), and fasting glucose (p, = 0.03); (3) IL-15R alpha SNP (rs2296135) and baseline total bone volume (p = 0.04) and the pre- to post-training absolute difference in isometric strength (p = 0.01); and 4) IL-15R alpha SNP (rs2228059) and serum triglycerides (p = 0.04), baseline whole muscle volume (p = 0.04), baseline cortical bone volume (p = 0.04), and baseline muscle quality (p, = 0.04). All associations were consistent in showing a potential involvement of the IL-15 pathway with muscle and bone phenotypes and predictors of metabolic syndrome. (C) 2008 Elsevier Ltd. All rights reserved.

    Journal Title

    Cytokine

    Volume

    43

    Issue/Number

    1

    Publication Date

    1-1-2008

    Document Type

    Article

    Language

    English

    First Page

    45

    Last Page

    53

    WOS Identifier

    WOS:000257823300006

    ISSN

    1043-4666

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