Title
CRMP3 is required for hippocampal CA1 dendritic organization and plasticity
Abbreviated Journal Title
Faseb J.
Keywords
Golgi analysis; gene targeting; neurite outgrowth; LTP; RESPONSE MEDIATOR PROTEINS; LONG-TERM POTENTIATION; GROWTH CONE; NEURONS; ACTIN; SYSTEM; MICE; PHOSPHORYLATION; INVOLVEMENT; EXPRESSION; Biochemistry & Molecular Biology; Biology; Cell Biology
Abstract
In vitro studies have pointed to the collapsin response mediator proteins (CRMPs) as key regulators of neurite outgrowth and axonal differentiation. CRMP3 is expressed mostly in the nervous system during development but remains at high levels in the hippocampus of adults. To explore CRMP3 function in vivo, we generated mice with targeted disruption of the CRMP3 gene. Immunohistochemistry and Golgi staining of CA1 showed abnormal dendrite and spine morphogenesis in the hippocampus of CRMP3-deficient mice. Apical dendrites displayed an increase in undulation and a reduction in length and branching points. Basal dendrites also exhibited a reduction in length with an alteration in soma stem distribution and an increased number of thick dendrites localized in stratum oriens (SO). Long-term potentiation (LTP) was impaired in this area. These data indicate an important role for CRMP3 in dendrite arborization, guide-posts navigation, and neuronal plasticity.
Journal Title
Faseb Journal
Volume
22
Issue/Number
2
Publication Date
1-1-2008
Document Type
Article
Language
English
First Page
401
Last Page
409
WOS Identifier
ISSN
0892-6638
Recommended Citation
"CRMP3 is required for hippocampal CA1 dendritic organization and plasticity" (2008). Faculty Bibliography 2000s. 860.
https://stars.library.ucf.edu/facultybib2000/860
Comments
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