Utilization of Fe3+-acinetoferrin analogs as an iron source by Mycobacterium tuberculosis

    Authors

    G. M. Rodriguez; R. Gardner; N. Kaur;O. Phanstiel

    Comments

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    Abbreviated Journal Title

    Biometals

    Keywords

    Mycobacterium tuberculosis; siderophores; iron; exosiderophores; acinetoferrin; mycobactin; DRUG DELIVERY AGENTS; MARINOBACTER-HYDROCARBONOCLASTICUS; SIDEROPHORE; BIOSYNTHESIS; ARTIFICIAL SIDEROPHORES; BIOLOGICAL EVALUATION; CITRATE; COMPLEX; CELL-WALL; PETROBACTIN; ACQUISITION; METABOLISM; Biochemistry & Molecular Biology

    Abstract

    Mycobacterium tuberculosis, the causative agent of human tuberculosis, synthesizes and secretes siderophores in order to compete for iron (an essential micronutrient). Successful iron acquisition allows M. tuberculosis to survive and proliferate under the iron-deficient conditions encountered in the host. To examine structural determinants important for iron siderophore transport in this pathogen, the citrate-based siderophores petrobactin, acinetoferrin and various acinetoferrin homologs were synthesized and used as iron transport probes. Mutant strains of M. tuberculosis deficient in native siderophore synthesis or transport were utilized to better understand the mechanisms involved in iron delivery via the synthetic siderophores. Acinetoferrin and its derivatives, especially those containing a cyclic imide group, were able to deliver iron or gallium into M. tuberculosis which promoted or inhibited, respectively, the growth of this pathogen.

    Journal Title

    Biometals

    Volume

    21

    Issue/Number

    1

    Publication Date

    1-1-2008

    Document Type

    Article

    Language

    English

    First Page

    93

    Last Page

    103

    WOS Identifier

    WOS:000252614800010

    ISSN

    0966-0844

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