Title

Utilization of Fe3+-acinetoferrin analogs as an iron source by Mycobacterium tuberculosis

Authors

Authors

G. M. Rodriguez; R. Gardner; N. Kaur;O. Phanstiel

Comments

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Abbreviated Journal Title

Biometals

Keywords

Mycobacterium tuberculosis; siderophores; iron; exosiderophores; acinetoferrin; mycobactin; DRUG DELIVERY AGENTS; MARINOBACTER-HYDROCARBONOCLASTICUS; SIDEROPHORE; BIOSYNTHESIS; ARTIFICIAL SIDEROPHORES; BIOLOGICAL EVALUATION; CITRATE; COMPLEX; CELL-WALL; PETROBACTIN; ACQUISITION; METABOLISM; Biochemistry & Molecular Biology

Abstract

Mycobacterium tuberculosis, the causative agent of human tuberculosis, synthesizes and secretes siderophores in order to compete for iron (an essential micronutrient). Successful iron acquisition allows M. tuberculosis to survive and proliferate under the iron-deficient conditions encountered in the host. To examine structural determinants important for iron siderophore transport in this pathogen, the citrate-based siderophores petrobactin, acinetoferrin and various acinetoferrin homologs were synthesized and used as iron transport probes. Mutant strains of M. tuberculosis deficient in native siderophore synthesis or transport were utilized to better understand the mechanisms involved in iron delivery via the synthetic siderophores. Acinetoferrin and its derivatives, especially those containing a cyclic imide group, were able to deliver iron or gallium into M. tuberculosis which promoted or inhibited, respectively, the growth of this pathogen.

Journal Title

Biometals

Volume

21

Issue/Number

1

Publication Date

1-1-2008

Document Type

Article

Language

English

First Page

93

Last Page

103

WOS Identifier

WOS:000252614800010

ISSN

0966-0844

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