A Stoichiometric Model of the Kinetics of Nanoparticle Clusterings Mediated by Antigen-Antibody Interactions

    Authors

    J. P. Brennan;T. Chen

    Comments

    Authors: contact us about adding a copy of your work at [email protected]

    Abbreviated Journal Title

    J. Comput. Theor. Nanosci.

    Keywords

    Immunoassay; Mass-Action Kinetic Model; Nanoparticles; Stoichiometry; DYNAMIC LIGHT-SCATTERING; INDUCED PARTICULATE AGGREGATION; AVERAGE; MOLECULAR-WEIGHTS; THEORETICAL-ANALYSIS; COMPLEXES; PROBES; IMMUNOASSAY; SENSORS; ASSAY; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials; Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter

    Abstract

    Mass action models have been used to model chemical reactions. We use the methods of stoichiometry to model the formation of nanoparticle clusterings where the bond between the nanoparticles is formed by antibody-antigen-antibody interaction. The growth of such configurations can be determined and the change of the mean nanoparticle size determined. This model can be used to determine the concentration of antigen in solution.

    Journal Title

    Journal of Computational and Theoretical Nanoscience

    Volume

    8

    Issue/Number

    9

    Publication Date

    1-1-2011

    Document Type

    Article

    Language

    English

    First Page

    1653

    Last Page

    1658

    WOS Identifier

    WOS:000298514100004

    ISSN

    1546-1955

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