Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions

    Authors

    J. A. Drewry; S. Fletcher; P. B. Yue; D. Marushchak; W. Zhao; S. Sharmeen; X. L. Zhang; A. D. Schimmer; C. Gradinaru; J. Turkson;P. T. Gunning

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    Abbreviated Journal Title

    Chem. Commun.

    Keywords

    MOLECULAR RECOGNITION; ARTIFICIAL RECEPTORS; CELL-TRANSFORMATION; SIGNAL; TRANSDUCER; GENE-REGULATION; STAT3; CANCER; TRANSCRIPTION-3; INHIBITION; ACTIVATION; Chemistry, Multidisciplinary

    Abstract

    We report the first application of coordination complexes as functional proteomimetics of the Src homology 2 (SH2) phosphopeptide-binding domain. As a proof-of-concept, functionalized bis-dipicolylamine (BDPA) copper(II) complexes are shown to disrupt oncogenic Stat3-Stat3 protein complexes and elicit promising anti-tumour activity.

    Journal Title

    Chemical Communications

    Volume

    46

    Issue/Number

    6

    Publication Date

    1-1-2010

    Document Type

    Article

    Language

    English

    First Page

    892

    Last Page

    894

    WOS Identifier

    WOS:000274070800012

    ISSN

    1359-7345

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