The 1p13.3 LDL (C)-Associated Locus Shows Large Effect Sizes in Young Populations

    Authors

    J. M. Devaney; P. D. Thompson; P. S. Visich; W. A. Saltarelli; P. M. Gordon; E. F. Orkunoglu-Suer; H. Gordish-Dressman; B. T. Harmon; M. K. Bradbury; K. Panchapakesan; R. Khianey; M. J. Hubal; P. M. Clarkson; L. S. Pescatello; R. F. Zoeller; N. M. Moyna; T. J. Angelopoulos; W. E. Kraus;E. P. Hoffman

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    Pediatr. Res.

    Keywords

    GENOME-WIDE ASSOCIATION; CIRCULATING OXIDIZED LDL; LOW-DENSITY-LIPOPROTEIN; METABOLIC SYNDROME; CHOLESTEROL; DISEASE; WOMEN; RISK; ADOLESCENTS; PREDICTION; Pediatrics

    Abstract

    Genome-wide association studies (GWASs) have identified polymorphic loci associated with coronary artery disease (CAD) risk factors (i.e. serum lipids) in adult populations (42-69 y). We hypothesized that younger populations would show a greater relative genetic component due to fewer confounding variables. We examined the influence of 20 GWAS loci associated with serum lipids and insulin metabolism, in a university student cohort (n = 548; mean age = 24 y), and replicated statistically associated results in a second study cohort of primary school students (n = 810, mean age = 11.5 y). Nineteen loci showed no relationship with studied risk factors in young adults. However, the ancestral allele of the rs646776 (SORT1) locus was strongly associated with increased LDL (C) in young adults [TT: 97.6 +/- 1.0 mg/dL (n = 345) versus CT/CC: 87.3 +/- 1.0 mg/dL (n = 203); p = 3 x 10(x6)] and children [TT: 94.0 +/- 1.3 mg/dL (n = 551) versus CT/CC: 84.7 +/- 1.4 mg/dL (n = 259); p = 4 X 10(x6)]. This locus is responsible for 3.6% of population variance in young adults and 2.5% of population variance in children. The effect size of the SORT1 locus is considerably higher in young populations (2.5-4.1%) compared with older subjects (1%). (Pediatr Res 69: 538-543, 2011)

    Journal Title

    Pediatric Research

    Volume

    69

    Issue/Number

    6

    Publication Date

    1-1-2011

    Document Type

    Article

    Language

    English

    First Page

    538

    Last Page

    543

    WOS Identifier

    WOS:000290831700012

    ISSN

    0031-3998

    Share

    COinS