Computational analysis and structure predictions of CHH-related peptides from Litopenaeus vannamei

    Authors

    G. P. C. Nagaraju; N. S. Kumari; G. L. V. Prasad; B. R. Naik;D. W. Borst

    Comments

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    Abbreviated Journal Title

    Integr. Biol.

    Keywords

    CRUSTACEAN HYPERGLYCEMIC HORMONE; MOLT-INHIBITING HORMONE; AMINO-ACID-SEQUENCE; MOLECULAR CHARACTERIZATION; HOMARUS-AMERICANUS; CARCINUS-MAENAS; CDNA CLONING; PROTEIN; SHRIMP; EXPRESSION; Cell Biology

    Abstract

    The crustaceans produce several related peptides that belong to the crustacean hyperglycemic hormone (CHH) family. While these peptides have similar amino acid sequences, they have diverse biological functions that must arise, in part, from differences in the 3D shape of these peptides. However, it is generally accepted that peptides with a high degree of sequence similarity also have a similar 3-D structure. We used the solution structure of one peptide in the crustacean hyperglycemic hormone family, the molt-inhibiting hormone of the kuruma prawn (Marsupenaeus japonicus), to predict the shape of the five known peptides related to CHH in the Pacific white shrimp, Litopenaeus vannamei. The high similarity of the 3-D structures of these peptides suggests a common fold for the entire family. Nevertheless, minor differences in the shape of these peptides were observed, which may be the basis for their different biological properties.

    Journal Title

    Integrative Biology

    Volume

    3

    Issue/Number

    3

    Publication Date

    1-1-2011

    Document Type

    Article

    Language

    English

    First Page

    218

    Last Page

    224

    WOS Identifier

    WOS:000288126800007

    ISSN

    1757-9694

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