MC4R Variant Is Associated With BMI but Not Response to Resistance Training in Young Females

    Authors

    F. E. Orkunoglu-Suer; B. T. Harmon; H. Gordish-Dressman; P. M. Clarkson; P. D. Thompson; T. J. Angelopoulos; P. M. Gordon; M. J. Hubal; N. M. Moyna; L. S. Pescatello; P. S. Visich; R. F. Zoeller; E. P. Hoffman;J. M. Devaney

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    Abbreviated Journal Title

    Obesity

    Keywords

    BODY-COMPOSITION; FTO GENOTYPE; STRENGTH; OBESITY; WEIGHT; CHILDHOOD; EXERCISE; PROGRAM; ENERGY; ADULT; Endocrinology & Metabolism; Nutrition & Dietetics

    Abstract

    Recently, a genome-wide association study (GWAS) that identified eight single-nucleotide polymorphisms (SNPs) associated with BMI highlighted a possible neuronal influence on the development of obesity. We hypothesized these SNPs would govern the response of BMI and subcutaneous fat to resistance training in young individuals (age = 24 years). We genotyped the eight GWAS-identified SNPs in the article by Willer et al. in a cohort (n = 796) that undertook a 12-week resistance-training program. Females with a copy of the rare allele (C) for rs17782313 (MC4R) had significantly higher BMIs (CC/CT: n = 174; 24.70 +/- 0.33 kg/m(2), TT: n = 278; 23.41 +/- 0.26 kg/m(2), P = 0.002), and the SNP explained 1.9% of overall variation in BMI. Males with a copy of the rare allele (T) for rs6548238 (TMEM18) had lower amounts of subcutaneous fat pretraining (CT/TT: n = 65; 156,534 +/- 7,415 mm(3), CC: n = 136; 177,825 +/- 5,139 mm(3), P = 0.019) and males with a copy of the rare allele (A) for rs9939609 (FTO) lost a significant amount of subcutaneous fat with exercise (AT/AA: n = 83; -798.35 +/- 2,624.30 mm(3), TT: n = 47; 9,435.23 +/- 3,494.44 mm(3), P = 0.021). Females with a copy of the G allele for a missense variant in the SH2B1 (rs7498665) was associated with less change of subcutaneous fat volume with exercise (AG/GG: n = 191; 9,813 +/- 2,250 mm(3) vs. AA: n = 126; 770 +/- 2,772 mm(3); P = 0.011). These data support the original finding that there is an association between measures of obesity and a variant near the MC4R gene and extends these results to a younger population and implicates FTO, TMEM18, and SH2B1 polymorphisms in subcutaneous fat regulation.

    Journal Title

    Obesity

    Volume

    19

    Issue/Number

    3

    Publication Date

    1-1-2011

    Document Type

    Article

    Language

    English

    First Page

    662

    Last Page

    666

    WOS Identifier

    WOS:000287648500031

    ISSN

    1930-7381

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