MC4R Variant Is Associated With BMI but Not Response to Resistance Training in Young Females
Abbreviated Journal Title
BODY-COMPOSITION; FTO GENOTYPE; STRENGTH; OBESITY; WEIGHT; CHILDHOOD; EXERCISE; PROGRAM; ENERGY; ADULT; Endocrinology & Metabolism; Nutrition & Dietetics
Recently, a genome-wide association study (GWAS) that identified eight single-nucleotide polymorphisms (SNPs) associated with BMI highlighted a possible neuronal influence on the development of obesity. We hypothesized these SNPs would govern the response of BMI and subcutaneous fat to resistance training in young individuals (age = 24 years). We genotyped the eight GWAS-identified SNPs in the article by Willer et al. in a cohort (n = 796) that undertook a 12-week resistance-training program. Females with a copy of the rare allele (C) for rs17782313 (MC4R) had significantly higher BMIs (CC/CT: n = 174; 24.70 +/- 0.33 kg/m(2), TT: n = 278; 23.41 +/- 0.26 kg/m(2), P = 0.002), and the SNP explained 1.9% of overall variation in BMI. Males with a copy of the rare allele (T) for rs6548238 (TMEM18) had lower amounts of subcutaneous fat pretraining (CT/TT: n = 65; 156,534 +/- 7,415 mm(3), CC: n = 136; 177,825 +/- 5,139 mm(3), P = 0.019) and males with a copy of the rare allele (A) for rs9939609 (FTO) lost a significant amount of subcutaneous fat with exercise (AT/AA: n = 83; -798.35 +/- 2,624.30 mm(3), TT: n = 47; 9,435.23 +/- 3,494.44 mm(3), P = 0.021). Females with a copy of the G allele for a missense variant in the SH2B1 (rs7498665) was associated with less change of subcutaneous fat volume with exercise (AG/GG: n = 191; 9,813 +/- 2,250 mm(3) vs. AA: n = 126; 770 +/- 2,772 mm(3); P = 0.011). These data support the original finding that there is an association between measures of obesity and a variant near the MC4R gene and extends these results to a younger population and implicates FTO, TMEM18, and SH2B1 polymorphisms in subcutaneous fat regulation.
"MC4R Variant Is Associated With BMI but Not Response to Resistance Training in Young Females" (2011). Faculty Bibliography 2010s. 1729.