Nucleic Acid Detection using MNAzymes

    Authors

    Y. V. Gerasimova;D. M. Kolpashchikov

    Comments

    Authors: contact us about adding a copy of your work at [email protected]

    Abbreviated Journal Title

    Chem. Biol.

    Keywords

    DNA ENZYME; Biochemistry & Molecular Biology

    Abstract

    Deoxyribozymes are promising biotechnological tools. In a recent JACS article, Mokany et al. reported on the design of multi-component deoxyribozyme (MNAzyme) sensors based on 10-23 and 8-17 DNA enzymes. The sensors can detect down to 5 pM of a specific nucleic acid. The versatility of MNAzyme platform allows the design of catalytic cascades for signal amplification. This work is a step forward to PCR-free molecular diagnostics.

    Journal Title

    Chemistry & Biology

    Volume

    17

    Issue/Number

    2

    Publication Date

    1-1-2010

    Document Type

    Editorial Material

    Language

    English

    First Page

    104

    Last Page

    106

    WOS Identifier

    WOS:000275897400004

    ISSN

    1074-5521

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