Title
Retrocyclins and their activity against HIV-1
Abbreviated Journal Title
Cell. Mol. Life Sci.
Keywords
Retrocyclin; Defensin; HIV-1; Host defense peptide; Antimicrobial; peptide; Antiviral; Microbicide; ANTIMICROBIAL PEPTIDE GOMESIN; CELL FUSION INHIBITOR; HERPES-SIMPLEX-VIRUS; THETA-DEFENSINS; SYNTHETIC PEPTIDE; MARKED; INCREASE; DENDRITIC CELLS; ALPHA-DEFENSINS; CYSTINE KNOT; IN-VITRO; Biochemistry & Molecular Biology; Cell Biology
Abstract
Primate theta-defensins are physically distinguished as the only known fully-cyclic peptides of animal origin. Humans do not produce theta-defensin peptides due to a premature stop codon present in the signal sequence of all six theta-defensin pseudogenes. Instead, since the putative coding regions of human theta-defensin pseudogenes have remained remarkably intact, their corresponding peptides, called "retrocyclins", have been recreated using solid-phase synthetic approaches. Retrocyclins exhibit an exceptional therapeutic index both as inhibitors of HIV-1 entry and as bactericidal agents, which makes retrocyclins promising candidates for further development as topical microbicides to prevent sexually transmitted diseases. This review presents the evolution, antiretroviral mechanism of action, and potential clinical applications of retrocyclins to prevent sexual transmission of HIV-1.
Journal Title
Cellular and Molecular Life Sciences
Volume
68
Issue/Number
13
Publication Date
1-1-2011
Document Type
Review
Language
English
First Page
2231
Last Page
2242
WOS Identifier
ISSN
1420-682X
Recommended Citation
"Retrocyclins and their activity against HIV-1" (2011). Faculty Bibliography 2010s. 1753.
https://stars.library.ucf.edu/facultybib2010/1753
Comments
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