Stem cells in the diabetic infarcted heart

    Authors

    C. E. Glass; P. K. Singal;D. K. Singla

    Comments

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    Abbreviated Journal Title

    Heart Fail. Rev.

    Keywords

    Diabetes; Embryonic stem cells; Myocardial infarction; Oxidative stress; Hyperglycemia; ACUTE MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; ANIMAL-MODELS; NITRIC-OXIDE; ENDOTHELIAL DYSFUNCTION; INSULIN-RESISTANCE; METABOLIC SYNDROME; CARDIAC-FUNCTION; RAT MODEL; Cardiac & Cardiovascular Systems

    Abstract

    Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant advances in pharmacological interventions and surgical techniques, the disease progression leading to diabetic end-stage heart failure remains very high. Recently, cell therapy has gained much attention as an alternative approach to treat various heart diseases. However, transplanted stem cell studies in diabetic animal models are very limited. In this review, we discuss the pathogenesis of the diabetic infarcted heart and the potential of stem cell therapy to repair and regenerate.

    Journal Title

    Heart Failure Reviews

    Volume

    15

    Issue/Number

    6

    Publication Date

    1-1-2010

    Document Type

    Article

    Language

    English

    First Page

    581

    Last Page

    588

    WOS Identifier

    WOS:000282426500005

    ISSN

    1382-4147

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