Title

Transcriptional regulation of co-expressed microRNA target genes

Authors

Authors

Y. Wang; X. M. Li;H. Y. Hu

Comments

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Abbreviated Journal Title

Genomics

Keywords

MicroRNA; Target gene; Co-expression; Co-regulation; Cis-regulatory; module; STATISTICAL SIGNIFICANCE; CAENORHABDITIS-ELEGANS; EXPRESSION; MODULES; IDENTIFICATION; PREDICTION; GENOME; ARABIDOPSIS; REPRESSION; DISCOVERY; Biotechnology & Applied Microbiology; Genetics & Heredity

Abstract

MicroRNAs play pivotal roles in gene regulation. Despite various research efforts on microRNAs, how microRNA target genes are transcriptionally regulated and how the transcriptional regulation of microRNA target genes relates to that of the microRNA genes are not well studied. By investigating the transcriptional regulation of microRNA target genes, we found that different groups of target genes of the same microRNA are co-expressed under different conditions, and these groups rarely overlap with each other for the majority of microRNAs. We also discovered that co-expressed microRNA target genes are often co-regulated, and different groups of target genes of the same microRNA are often regulated differently. In addition, we observed that transcription factors regulating a microRNA gene often regulate its target genes. Our study sheds light on the regulation of microRNA target genes, which will facilitate the prediction of microRNA target genes and the understanding of the transcriptional regulation of microRNA genes. (C) 2011 Elsevier Inc. All rights reserved.

Journal Title

Genomics

Volume

98

Issue/Number

6

Publication Date

1-1-2011

Document Type

Article

Language

English

First Page

445

Last Page

452

WOS Identifier

WOS:000297664700006

ISSN

0888-7543

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