The Collapsin Response Mediator Protein 5 Onconeural Protein Is Expressed in Schwann Cells Under Axonal Signals and Regulates Axon-Schwann Cell Interactions

    Authors

    J. P. Camdessanche; K. Ferraud; N. Boutahar; F. Lassabliere; M. Mutter; M. Touret; P. Kolattukudy; J. Honnorat;J. C. Antoine

    Comments

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    Abbreviated Journal Title

    J. Neuropathol. Exp. Neurol.

    Keywords

    CRMP5; Paraneoplastic neurologic syndromes; Peripheral neuropathy; Schwann cells; GROWTH-CONE COLLAPSE; MOLECULAR CHARACTERIZATION; DIFFERENTIAL; EXPRESSION; NEURITE OUTGROWTH; PERIPHERAL-NERVE; MOUSE-BRAIN; RHO-KINASE; MYELINATION; NEURONS; SYSTEM; Clinical Neurology; Neurosciences; Pathology

    Abstract

    Collapsin response mediator protein 5 (CRMP5) is one of the rare peripheral nerve antigens that is a target of autoantibodies in a paraneoplastic peripheral neuropathy. The pattern of axonal and myelin alterations suggests that CRMP5 is involved in axon-Schwann cell interaction. We examined CRMP5 expression and function in primary cultures of Schwann cells and neurons and at various developmental and regenerating stages of rat sciatic nerve and in CRMP5-deficient mice in vivo. Collapsin response mediator protein 5 was strongly expressed during postnatal development and regeneration and decreased with myelination. It was mainly expressed by immature Schwann cells and persisted in Remak cells in the adult; however, a subpopulation of Schwann cells that were induced to myelinate also expressed CRMP5. We identified 2 axonal molecular cues regulating CRMP5 expression: human neuregulin type 1, which induces CRMP5 expression in immature and premyelinating Schwann cells, and cyclic adenosine monophosphate, which inhibits CRMP5 expression when Schwann cells begin myelination. Collapsin response mediator protein 5-deficient mice showed abnormal Schwann process extension resulting in abnormal cell-axon segregation, indicating that CRMP5 is involved in the morphologic adaptation of Schwann cells to surround axons. These results demonstrate the importance of CRMP5 in axon-Schwann cell cooperation during development and regeneration.

    Journal Title

    Journal of Neuropathology and Experimental Neurology

    Volume

    71

    Issue/Number

    4

    Publication Date

    1-1-2012

    Document Type

    Article

    Language

    English

    First Page

    298

    Last Page

    311

    WOS Identifier

    WOS:000302178700004

    ISSN

    0022-3069

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