Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of A beta aggregates modulate neuronal survival pathways

    Authors

    A. Cimini; B. D'Angelo; S. Das; R. Gentile; E. Benedetti; V. Singh; A. M. Monaco; S. Santucci;S. Seal

    Comments

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    Abbreviated Journal Title

    Acta Biomater.

    Keywords

    Cerium oxide nanoparticle; Targeted therapy; Neurodegeneration; Nanoparticles; Neurotrophins; NEURODEGENERATIVE DISEASES; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; POLYPHENOLIC COMPOUNDS; CEREBRAL-ISCHEMIA; DELIVERY; BRAIN; NEUROPROTECTION; NEUROTOXICITY; MECHANISMS; Engineering, Biomedical; Materials Science, Biomaterials

    Abstract

    Oxidative stress has been found to be associated with the progression of neurodegenerative diseases such as Alzheimer's, Parkinson's, Lou Gehrig's, etc. In the recent years, cerium oxide nanoparticles (CNPs) have been studied as potent antioxidant agents able to exert neuroprotective effects. This work reports polyethylene glycol (PEG)-coated and antibody-conjugated CNPs for the selective delivering to A beta aggregates, and the protective effect against oxidative stress/A beta-mediated neurodegeneration. In this study PEG-coated and anti-A beta antibody-conjugated antioxidant nanoparticles (A beta-CNPs-PEG) were developed, and their effects on neuronal survival and brain-derived neurotrophic factor (BDNF) signaling pathway were examined. A beta-CNPs-PEG specifically targets the A beta aggregates, and concomitant rescue of neuronal survival better than A beta-CNPs, by modulating the BDNF signaling pathway. This proof of concept work may allow in the future, once validated in vivo, for the selective delivery of CNPs only to affected brain areas. Published by Elsevier Ltd. on behalf of Acta Materialia Inc.

    Journal Title

    Acta Biomaterialia

    Volume

    8

    Issue/Number

    6

    Publication Date

    1-1-2012

    Document Type

    Article

    Language

    English

    First Page

    2056

    Last Page

    2067

    WOS Identifier

    WOS:000305036100005

    ISSN

    1742-7061

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