Title
Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of A beta aggregates modulate neuronal survival pathways
Abbreviated Journal Title
Acta Biomater.
Keywords
Cerium oxide nanoparticle; Targeted therapy; Neurodegeneration; Nanoparticles; Neurotrophins; NEURODEGENERATIVE DISEASES; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; POLYPHENOLIC COMPOUNDS; CEREBRAL-ISCHEMIA; DELIVERY; BRAIN; NEUROPROTECTION; NEUROTOXICITY; MECHANISMS; Engineering, Biomedical; Materials Science, Biomaterials
Abstract
Oxidative stress has been found to be associated with the progression of neurodegenerative diseases such as Alzheimer's, Parkinson's, Lou Gehrig's, etc. In the recent years, cerium oxide nanoparticles (CNPs) have been studied as potent antioxidant agents able to exert neuroprotective effects. This work reports polyethylene glycol (PEG)-coated and antibody-conjugated CNPs for the selective delivering to A beta aggregates, and the protective effect against oxidative stress/A beta-mediated neurodegeneration. In this study PEG-coated and anti-A beta antibody-conjugated antioxidant nanoparticles (A beta-CNPs-PEG) were developed, and their effects on neuronal survival and brain-derived neurotrophic factor (BDNF) signaling pathway were examined. A beta-CNPs-PEG specifically targets the A beta aggregates, and concomitant rescue of neuronal survival better than A beta-CNPs, by modulating the BDNF signaling pathway. This proof of concept work may allow in the future, once validated in vivo, for the selective delivery of CNPs only to affected brain areas. Published by Elsevier Ltd. on behalf of Acta Materialia Inc.
Journal Title
Acta Biomaterialia
Volume
8
Issue/Number
6
Publication Date
1-1-2012
Document Type
Article
Language
English
First Page
2056
Last Page
2067
WOS Identifier
ISSN
1742-7061
Recommended Citation
"Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of A beta aggregates modulate neuronal survival pathways" (2012). Faculty Bibliography 2010s. 2427.
https://stars.library.ucf.edu/facultybib2010/2427
Comments
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