Title

Alterations in Osteopontin Modify Muscle Size in Females in Both Humans and Mice

Authors

Authors

E. P. Hoffman; H. Gordish-Dressman; V. D. McLane; J. M. Devaney; P. D. Thompson; P. Visich; P. M. Gordon; L. S. Pescatello; R. F. Zoeller; N. M. Moyna; T. J. Angelopoulos; E. Pegoraro; G. A. Cox;P. M. Clarkson

Comments

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Abbreviated Journal Title

Med. Sci. Sports Exerc.

Keywords

OSTEOPONTIN (OPN); SECRETED PHOSPHOPROTEIN 1 (SPP1); GENETIC; POLYMORPHISM; ESTROGEN; HYPERTROPHY; MRI; ACTN3 GENOTYPE; IN-VIVO; STRENGTH; IDENTIFICATION; POLYMORPHISMS; REGENERATION; GENE; ASSOCIATION; PERFORMANCE; INDUCTION; Sport Sciences

Abstract

Purpose: An osteopontin (OPN; SPP1) gene promoter polymorphism modifies disease severity in Duchenne muscular dystrophy, and we hypothesized that it might also modify muscle phenotypes in healthy volunteers. Methods: Gene association studies were carried out for OPN (rs28357094) in the FAMuSS cohort (n = 752; mean +/- SD age = 23.7 +/- 5.7 yr). The phenotypes studied included muscle size (MRI), strength, and response to supervised resistance training. We also studied 147 young adults that had carried out a bout of eccentric elbow exercise (age = 24.0 +/- 5.2 yr). Phenotypes analyzed included strength, soreness, and serum muscle enzymes. Results: In the FAMuSS cohort, the G allele was associated with 17% increase in baseline upper arm muscle volume only in women (F = 26.32; P = 5.32 x 10(-7)), explaining 5% of population variance. In the eccentric damage cohort, weak associations of the G allele were seen in women with both baseline myoglobin and elevated creatine kinase. The sexually dimorphic effects of OPN on muscle were also seen in OPN-null mice. Five of seven muscle groups examined showed smaller size in OPN-null female mice, whereas two were smaller in male mice. The query of OPN gene transcription after experimental muscle damage in mice showed rapid induction within 12 h (100-fold increase from baseline), followed by sustained high-level expression through 16 d of regeneration before falling to back to baseline. Conclusion: OPN is a sexually dimorphic modifier of muscle size in normal humans and mice and responds to muscle damage. The OPN gene is known to be estrogen responsive, and this may explain the female-specific genotype effects in adult volunteers.

Journal Title

Medicine and Science in Sports and Exercise

Volume

45

Issue/Number

6

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

1060

Last Page

1068

WOS Identifier

WOS:000319323300006

ISSN

0195-9131

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