Phosphatidylserine and caffeine attenuate postexercise mood disturbance and perception of fatigue in humans

    Authors

    A. J. Wells; J. R. Hoffman; A. M. Gonzalez; J. R. Stout; M. S. Fragala; G. T. Mangine; W. P. McCormack; A. R. Jajtner; J. R. Townsend;E. H. Robinson

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    Abbreviated Journal Title

    Nutr. Res.

    Keywords

    Cognition; Mood; Reaction time; Double-blind study; Randomized; controlled trial; Dietary supplements; MEMORY IMPAIRMENT; COGNITIVE PERFORMANCE; FUNCTIONAL FATIGUE; PROTEIN-KINASE; REACTION-TIME; EXERCISE; STRESS; SUPPLEMENTATION; METABOLISM; ACTIVATION; Nutrition & Dietetics

    Abstract

    Phosphatidylserine (PS) may attenuate the adverse effects of physical fatigue. Therefore, we investigated the effects of a multi-ingredient supplement containing 400 mg/d PS and 100 mg/d caffeine (supplement [SUP]) for 2 weeks on measures of cognitive function (CF), reaction time (RT), and mood (MD) following an acute exercise stress. It is hypothesized that PS will maintain preexercise CF and RT scores, while attenuating postexercise fatigue. Participants completed 2 acute bouts of resistance exercise (T1 and T2) separated by 2-week ingestion of SUP or control (CON). Outcome measures were assessed pre- and postexercise. When collapsed across groups, a significant decrease in RT performance was seen in the 60-second reaction drill from pre- to postexercise at T1. All other RT tests were similar from pre- to postexercise at T1. Reaction time was not significantly changed by PS. When collapsed across groups, a significant increase in performance of the serial subtraction test was seen. A significant increase (8.9% and 7.1%) in the number of correct answers and a significant decrease (8.0% and 7.5%) in time to answer were seen from pre- to postworkout at T1 and T2, respectively. A significant increase in total MD score from pre- to postworkout was observed for CON but not for PS at T2. Phosphatidylserine significantly attenuated pre- to postexercise perception of fatigue compared to CON. Ingestion of SUP for 14 days appears to attenuate postexercise MD scores and perception of fatigue, but does not affect CF or RT, in recreationally trained individuals. (C) 2013 Elsevier Inc. All rights reserved.

    Journal Title

    Nutrition Research

    Volume

    33

    Issue/Number

    6

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    464

    Last Page

    472

    WOS Identifier

    WOS:000321317800005

    ISSN

    0271-5317

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