Tyrosine nitration as mediator of cell death

    Authors

    M. C. Franco;A. G. Estevez

    Comments

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    Abbreviated Journal Title

    Cell. Mol. Life Sci.

    Keywords

    Tyrosine nitration; Cell death; Reactive nitrogen species; Peroxynitrite; Nitrated Hsp90; MANGANESE-SUPEROXIDE-DISMUTASE; PEROXYNITRITE-INDUCED APOPTOSIS; AMYOTROPHIC-LATERAL-SCLEROSIS; NITRIC-OXIDE SYNTHASE; LIVER; PLASMA-MEMBRANE; SPINAL-CORD-INJURY; DEPENDENT PROTEIN NITRATION; ALZHEIMERS-DISEASE BRAIN; OXIDATIVE STRESS; CYTOCHROME-C; Biochemistry & Molecular Biology; Cell Biology

    Abstract

    Nitrotyrosine is used as a marker for the production of peroxynitrite and other reactive nitrogen species. For over 20 years the presence of nitrotyrosine was associated with cell death in multiple pathologies. Filling the gap between correlation and causality has proven to be a difficult task. Here, we discuss the evidence supporting tyrosine nitration as a specific posttranslational modification participating in the induction of cell death signaling pathways.

    Journal Title

    Cellular and Molecular Life Sciences

    Volume

    71

    Issue/Number

    20

    Publication Date

    1-1-2014

    Document Type

    Article

    Language

    English

    First Page

    3939

    Last Page

    3950

    WOS Identifier

    WOS:000342420300005

    ISSN

    1420-682X

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