Connectable DNA Logic Gates: OR and XOR Logics

    Authors

    Y. V. Gerasimova;D. M. Kolpashchikov

    Comments

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    Abbreviated Journal Title

    Chem.-Asian J.

    Keywords

    DNA; logic gates; molecular beacons; molecular computing; nanotechnology; MOLECULAR BEACONS; HYBRIDIZATION KINETICS; NUCLEIC-ACIDS; CIRCUITS; PROBE; DEOXYRIBOZYME; JUNCTIONS; APTAMERS; DEVICES; DESIGN; Chemistry, Multidisciplinary

    Abstract

    Modern computer processors are based on semiconductor logic gates connected to each other in complex circuits. This study contributes to the development of a new class of connectable logic gates made of DNA in which the transfer of oligonucleotide fragments as input/output signals occurs upon hybridization of DNA sequences. The DNA strands responsible for a logic function form associates containing immobile DNA four-way junction structures when the signal is high and dissociate into separate strands when the signal is low. A basic set of logic gates (NOT, AND, and OR) was designed. Two NOT gates, two AND gates, and an OR gate were connected in a network that corresponds to an XOR logic function. The design of the logic gates presented here may contribute to the development of the first biocompatible molecular computer.

    Journal Title

    Chemistry-an Asian Journal

    Volume

    7

    Issue/Number

    3

    Publication Date

    1-1-2012

    Document Type

    Article

    Language

    English

    First Page

    534

    Last Page

    540

    WOS Identifier

    WOS:000300871500012

    ISSN

    1861-4728

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