Abbreviated Journal Title
Appl. Phys. Lett.
Keywords
PROSTATE-CANCER; BREAST; TISSUES; ELEMENTS; COLON; BONE; LEAD; Physics, Applied
Abstract
Multiple DNA and protein biomarkers have been detected based on characteristic x-ray fluorescence of a panel of metal and alloy nanoparticles, which are modified with ligands of biomarkers to create a one-to-one correspondence and immobilized on ligand-modified substrates after forming complexes with target biomarkers in three-strand or sandwich configuration. By determining the presence and concentration of nanoparticles using x-ray fluorescence, the nature and amount of biomarkers can be detected with limits of 1 nM for DNA and 1 ng/ml for protein. By combining high penetrating ability of x-rays, this method allows quantitative imaging of multiple biomarkers.
Journal Title
Applied Physics Letters
Volume
97
Issue/Number
26
Publication Date
1-1-2010
Document Type
Article
DOI Link
Language
English
First Page
3
WOS Identifier
ISSN
0003-6951
Recommended Citation
Hossain, Mainul; Wang, Chaoming; and Su, Ming, "Multiplexed biomarker detection using x-ray fluorescence of composition-encoded nanoparticles" (2010). Faculty Bibliography 2010s. 267.
https://stars.library.ucf.edu/facultybib2010/267
Comments
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“This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in this linked citation and may be found at Applied Physics Letters."