L-glutamine absorption is enhanced after ingestion of L-alanylglutamine compared with the free amino acid or wheat protein

    Authors

    R. C. Harris; J. R. Hoffman; A. Allsopp;N. B. H. Routledge

    Comments

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    Abbreviated Journal Title

    Nutr. Res.

    Keywords

    L-glutamine; L-alanylglutamine; Wheat protein; Absorption; Supplements; Males; ALANYL-L-GLUTAMINE; WATER-ABSORPTION; DEGRADATION KINETICS; PARENTERAL-NUTRITION; DIPEPTIDE ABSORPTION; EXHAUSTIVE EXERCISE; ORAL; REHYDRATION; AQUEOUS-SOLUTION; IMMUNE-RESPONSE; HUMAN INTESTINE; Nutrition & Dietetics

    Abstract

    Differences in plasma L-glutamine (L-Gln) concentrations from ingestion of different formulations of L-Gln were examined in 8 men (26.8 +/- 4.2 years old, 181.1 +/- 10.9 cm, 85.8 +/- 15.4 kg). Subjects reported to the laboratory on 4 separate occasions and randomly consumed 1 of 4drinks containing 60 mg/kg of L-Gln; 89 mg/kg of Sustamine (L-alanylglutamine [AlaGln]; Kyowa Hakko Europe GmbH, Dusseldorf, Germany), which contained an equivalent L-Gln dose as consumed in L-Gln); 200 mg/kg of an enzymatically hydrolyzed wheat protein (HWP) with an L-Gln content of 31 mg/kg; or a control that consisted only of water. It was hypothesized that the AlaGln trial would increase plasma glutamine concentrations greater than the other experimental trials. Ingestion of L-Gln, AlaGln, and HWP resulted in significant increases in the plasma L-Gln concentration, peaking at 0.5, 0.5, and 0.75 hours, respectively. The corresponding mean peak increases were 179 +/- 61, 284 +/- 84, and 134 +/- 36 mu mol/L, respectively. Concentrations returned to baseline in all subjects by 2 hours after L-Gln and HWP and by 4 hours after AlaGln. Mean areas under the plasma concentration curve, calculated between 0 and 4 hours, were 127 +/- 61, 284 +/- 154, and 151 +/- 63 mu mol(.)h(.)L(-1) for L-Gln, AlaGln, and HWP, respectively. When allowance was made for the lower L-Gln dose administered as HWP, the peak plasma concentration and area under the plasma concentration curve were approximately the same as for AlaGln. The results suggest a greater transfer from the gut to plasma of L-Gln when supplied as AlaGln and possibly also as HWP compared with when the same dose was provided as the free amino acid. (C) 2012 Elsevier Inc. All rights reserved.

    Journal Title

    Nutrition Research

    Volume

    32

    Issue/Number

    4

    Publication Date

    1-1-2012

    Document Type

    Article

    Language

    English

    First Page

    272

    Last Page

    277

    WOS Identifier

    WOS:000305264200006

    ISSN

    0271-5317

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