Nanoparticle Location and Material-Dependent Dose Enhancement in X-ray Radiation Therapy

    Authors

    M. Hossain;M. Su

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    J. Phys. Chem. C

    Keywords

    NANOSCALE ENERGY DEPOSITION; BISMUTH SULFIDE NANOPARTICLES; GOLD; NANOPARTICLES; MONTE-CARLO; BRACHYTHERAPY; CANCER; RADIOTHERAPY; NUCLEUS; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, ; Multidisciplinary

    Abstract

    Nanoparticles of high atomic number (Z) materials can act as radiosensitizers to enhance radiation dose delivered to tumors. An analytical approach is used to calculate dose enhancements to tumor endothelial cells and their nuclei for a series of nanoparticles (bismuth, gold and platinum) located at different locations relative to nuclei by considering contributions from both photoelectrons and Auger electrons. The ratio of the dose delivered to cells with and without the nanoparticles is known as the dose enhancement factor (DEF). DEFs depend on material composition, size, and location of nanoparticles with respect to the cell and the nucleus. Energy of irradiating X-ray beam affects X-ray absorption by nanoparticles and plays an important role in dose enhancements. For diagnostic X-ray sources, bismuth nanoparticles provide higher dose enhancements than gold and platinum nanoparticles for a given nanoparticle size, concentration and location. The highest DEFs are achieved for nanoparticles located closest to the nucleus, where energy depositions from short-range Auger electrons are maximum. With nanoparticles ranging in diameter between 2 and 400 nm, the dose enhancement increases with decrease in particle size. The results are useful in finding optimized conditions for nanoparticle-enhanced X-ray radiation therapy

    Journal Title

    Journal of Physical Chemistry C

    Volume

    116

    Issue/Number

    43

    Publication Date

    1-1-2012

    Document Type

    Article

    Language

    English

    First Page

    23047

    Last Page

    23052

    WOS Identifier

    WOS:000310482900050

    ISSN

    1932-7447

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