Title

A cerium oxide nanoparticle-based device for the detection of chronic inflammation via optical and magnetic resonance imaging

Authors

Authors

C. Kaittanis; S. Santra; A. Asati;J. M. Perez

Comments

Authors: contact us about adding a copy of your work at STARS@ucf.edu

Abbreviated Journal Title

Nanoscale

Keywords

CELLULAR HYDROGEN-PEROXIDE; CANCER-THERAPY; QUANTUM DOTS; CYTOTOXICITY; NEUTROPHILS; GENERATION; EXPOSURE; DISEASES; H2O2; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials; Science, Multidisciplinary; Physics, Applied

Abstract

Monitoring of microenvironmental parameters is critical in healthcare and disease management. Harnessing the antioxidant activity of nanoceria and the imaging capabilities of iron oxide nanoparticles in a device setup, we were able to image changes in the device's aqueous milieu. The device was able to convey and process changes in the microenvironment's pH and reactive oxygen species' concentration, distinguishing physiological from abnormal levels. As a result under physiological and transient inflammatory conditions, the device's fluorescence and magnetic resonance signals, emanating from multimodal iron oxide nanoparticles, were similar. However, under chronic inflammatory conditions that are usually associated with high local concentrations of reactive oxygen species and pH decrease, the device's output was considerably different. Specifically, the device's fluorescence emission significantly decreased, while the magnetic resonance signal T2 increased. Further studies identified that the changes in the device's output are attributed to inactivation of the sensing component's nanoceria that prevents it from successfully scavenging the generated free radicals. Interestingly, the buildup of free radical excess led to polymerization of the iron oxide nanoparticle's coating, with concomitant formation of micron size aggregates. Our studies indicate that a nanoceria-based device can be utilized for the monitoring of pro-inflammatory biomarkers, having important applications in the management of numerous ailments while eliminating nanoparticle toxicity issues.

Journal Title

Nanoscale

Volume

4

Issue/Number

6

Publication Date

1-1-2012

Document Type

Article

Language

English

First Page

2117

Last Page

2123

WOS Identifier

WOS:000301000900033

ISSN

2040-3364

Share

COinS