A cerium oxide nanoparticle-based device for the detection of chronic inflammation via optical and magnetic resonance imaging

    Authors

    C. Kaittanis; S. Santra; A. Asati;J. M. Perez

    Comments

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    Abbreviated Journal Title

    Nanoscale

    Keywords

    CELLULAR HYDROGEN-PEROXIDE; CANCER-THERAPY; QUANTUM DOTS; CYTOTOXICITY; NEUTROPHILS; GENERATION; EXPOSURE; DISEASES; H2O2; Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials; Science, Multidisciplinary; Physics, Applied

    Abstract

    Monitoring of microenvironmental parameters is critical in healthcare and disease management. Harnessing the antioxidant activity of nanoceria and the imaging capabilities of iron oxide nanoparticles in a device setup, we were able to image changes in the device's aqueous milieu. The device was able to convey and process changes in the microenvironment's pH and reactive oxygen species' concentration, distinguishing physiological from abnormal levels. As a result under physiological and transient inflammatory conditions, the device's fluorescence and magnetic resonance signals, emanating from multimodal iron oxide nanoparticles, were similar. However, under chronic inflammatory conditions that are usually associated with high local concentrations of reactive oxygen species and pH decrease, the device's output was considerably different. Specifically, the device's fluorescence emission significantly decreased, while the magnetic resonance signal T2 increased. Further studies identified that the changes in the device's output are attributed to inactivation of the sensing component's nanoceria that prevents it from successfully scavenging the generated free radicals. Interestingly, the buildup of free radical excess led to polymerization of the iron oxide nanoparticle's coating, with concomitant formation of micron size aggregates. Our studies indicate that a nanoceria-based device can be utilized for the monitoring of pro-inflammatory biomarkers, having important applications in the management of numerous ailments while eliminating nanoparticle toxicity issues.

    Journal Title

    Nanoscale

    Volume

    4

    Issue/Number

    6

    Publication Date

    1-1-2012

    Document Type

    Article

    Language

    English

    First Page

    2117

    Last Page

    2123

    WOS Identifier

    WOS:000301000900033

    ISSN

    2040-3364

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