Perioperative fluid balance and acute kidney injury
Abbreviated Journal Title
Clin. Exp. Nephrol.
Keywords
Fluid balance; AKI; CRITICALLY-ILL PATIENTS; CARDIAC-SURGERY; SURVIVAL; ACCUMULATION; MORTALITY; Urology & Nephrology
Abstract
Positive fluid balance (FB) has been linked to adverse clinical outcomes. We performed this study to explore the relationship between perioperative fluid balance and acute kidney injury (AKI). The relationships between FB and AKI were explored using a prospective, observational design. Patients were divided into quartiles based on FB status in the first 24 h from initiation of surgery in order to further explore this relationship. One hundred adult patients undergoing cardiovascular surgery were included in the analysis. The major finding of the study was that positive FB occurred early in the intraoperative period and progressed into the postoperative period and that fluid administration was not clearly associated with any identifiable volume-sensitive event. The evolution of positive FB preceded the rise in serum creatinine. Progressive severity of positive FB was associated with increased incidence of AKI. The highest quartile FB group had a five-fold increased risk for AKI (adjusted odds ratio 4.98, 95 % confidence interval 1.38-24.10, p = 0.046) compared to the lowest quartile group, higher postoperative peak serum creatinine values (p < 0.001), surgery-related complications (p < 0.001) and intensive care unit (p < 0.001) and hospital length of stay (p = 0.048). Positive FB was associated with increased incidence of AKI.
Journal Title
Clinical and Experimental Nephrology
Volume
16
Issue/Number
5
Publication Date
1-1-2012
Document Type
Article
Language
English
First Page
730
Last Page
738
WOS Identifier
ISSN
1342-1751
Recommended Citation
"Perioperative fluid balance and acute kidney injury" (2012). Faculty Bibliography 2010s. 2823.
https://stars.library.ucf.edu/facultybib2010/2823
Comments
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