Authors

S. K. Lahiri;J. H. Zhao

Comments

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Abbreviated Journal Title

Am. J. Transl. Res.

Keywords

Kruppel-like factor 8 (KLF8); cancer; FOCAL ADHESION KINASE; CELL-CYCLE PROGRESSION; KLF8 TRANSCRIPTION; IN-VIVO; IDENTIFICATION; GENE; ACTIVATION; EXPRESSION; INVASION; FINGERS; Oncology; Medicine, Research & Experimental

Abstract

Kruppel-like factor 8 (KLF8) is a young member of the KLF transcription factor family proteins. It is highly overexpressed in several types of human cancers and regulates various cellular processes important for tumor progression. Increasing evidence has made KLF8 a new focus in cancer research and a potential target for cancer therapy. This review highlights the role of KLF8 in cancer by summarizing the up-to-date studies into its structure, function as a dual transcription factor, target genes and mechanisms of expression and modifications.

Journal Title

American Journal of Translational Research

Volume

4

Issue/Number

3

Publication Date

1-1-2012

Document Type

Review

Language

English

First Page

357

Last Page

363

WOS Identifier

WOS:000318279500010

ISSN

1943-8141

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