Targeting selenium metabolism and selenoproteins: Novel avenues for drug discovery

    Authors

    S. E. Jackson-Rosario;W. T. Self

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    Metallomics

    Keywords

    CLOSTRIDIAL GLYCINE REDUCTASE; SELD GENE-PRODUCT; THIOREDOXIN REDUCTASE; CANCER-THERAPY; MAMMALIAN THIOREDOXIN; TRANSFER-RNA; TREPONEMA-DENTICOLA; ANTICANCER ACTIVITY; ESCHERICHIA-COLI; ARSENIC; TRIOXIDE; Biochemistry & Molecular Biology

    Abstract

    Selenoproteins play a wide range of roles in metabolism and oxidative stress defense and are produced by organisms in all three domains of life. Recent evidence has been presented that metal based cancer drugs target the selenol nucleophile of the active site selenocysteine in thioredoxin reductase isoenzymes. Other metals and metalloids, such as tin, arsenic and gold, have also recently been shown to form stable complexes with hydrogen selenide, a required precursor for the synthesis of selenoproteins in all biological organisms. Moreover these metal based compounds have been shown to inhibit growth of pathogens such as Clostridium dificile and Treponema denticola due to their reactivity with this highly reactive metabolic precursor. This review summarizes the recent finding on these two avenues for drug discovery, and puts this work in context with the larger field of selenium biology.

    Journal Title

    Metallomics

    Volume

    2

    Issue/Number

    2

    Publication Date

    1-1-2010

    Document Type

    Article; Proceedings Paper

    Language

    English

    First Page

    112

    Last Page

    116

    WOS Identifier

    WOS:000274397000003

    ISSN

    1756-5901

    Share

    COinS