Title

On-chip radiation biodosimetry with three-dimensional microtissues

Authors

Authors

Y. Luo; M. Hossain; C. M. Wang; Y. Qiao; L. Y. Ma;M. Su

Comments

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Abbreviated Journal Title

Analyst

Keywords

CELLS; PHONE; ASSAY; Chemistry, Analytical

Abstract

This paper reports an image-based, on-chip microtissue radiation biodosimeter that can simultaneously monitor radiation responses of multiple mammalian cell types. The microtissue chip is fabricated by molding molten agarose gel onto microfabricated patterns to form microwells, and seeding a variety of cell suspensions into different microwells inside the agarose gel. The camera of a mobile phone is used to collect images of an array of microtissues, and the color changes of microtissues upon X-ray irradiation allow accurate determination of cell death, which is related to radiation dose. The images can be transferred wirelessly, allowing the biodosimeter to be used for convenient and field deployable monitoring of radiation exposure.

Journal Title

Analyst

Volume

137

Issue/Number

15

Publication Date

1-1-2012

Document Type

Article

Language

English

First Page

3441

Last Page

3444

WOS Identifier

WOS:000305882700007

ISSN

0003-2654

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