On-chip radiation biodosimetry with three-dimensional microtissues

    Authors

    Y. Luo; M. Hossain; C. M. Wang; Y. Qiao; L. Y. Ma;M. Su

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    Analyst

    Keywords

    CELLS; PHONE; ASSAY; Chemistry, Analytical

    Abstract

    This paper reports an image-based, on-chip microtissue radiation biodosimeter that can simultaneously monitor radiation responses of multiple mammalian cell types. The microtissue chip is fabricated by molding molten agarose gel onto microfabricated patterns to form microwells, and seeding a variety of cell suspensions into different microwells inside the agarose gel. The camera of a mobile phone is used to collect images of an array of microtissues, and the color changes of microtissues upon X-ray irradiation allow accurate determination of cell death, which is related to radiation dose. The images can be transferred wirelessly, allowing the biodosimeter to be used for convenient and field deployable monitoring of radiation exposure.

    Journal Title

    Analyst

    Volume

    137

    Issue/Number

    15

    Publication Date

    1-1-2012

    Document Type

    Article

    Language

    English

    First Page

    3441

    Last Page

    3444

    WOS Identifier

    WOS:000305882700007

    ISSN

    0003-2654

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