Authors

G. T. Mangine; A. M. Gonzalez; A. J. Wells; W. P. McCormack; M. S. Fragala; J. R. Stout;J. R. Hoffman

Comments

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Abbreviated Journal Title

Lipids Health Dis.

Keywords

Dietary Adherence; Appetite; Obesity; Green Tea Extract; GREEN TEA POLYPHENOL; CATECHOL-O-METHYLTRANSFERASE; WEIGHT-LOSS; OBESE; WOMEN; RISK; OLEOYLETHANOLAMIDE; EXERCISE; SIBUTRAMINE; ACTIVATION; INHIBITION; Biochemistry & Molecular Biology; Nutrition & Dietetics

Abstract

Background: A dietary supplement containing a blend of 170 mg of N-oleyl-phosphatidylethanolamine (NOPE) and 100 mg of epigallocatechin-3-gallate (EGCG) has been shown to improve compliance to low caloric diets. Considering the cost of dietary ingredients, many manufacturers attempt to determine the lowest efficacious dose. Thus, the purpose of this study was to evaluate the efficacy of 8-weeks of supplementation with a daily intake of 120 mg of NOPE and 105 mg of EGCG in conjunction with a low caloric diet and regular, moderate exercise on dietary compliance in healthy, overweight adults. An additional purpose was to examine the effect of this supplement/diet/exercise paradigm on changes in body composition, sensation of appetite, mood and severity of binge eating. Methods: Fifty healthy, overweight (BMI > 25 m.kg(2)) men (15) and women (35) (SUP; n = 25; 32.7 +/- 13.75 y; BMI = 33.4 +/- 6.2; PLA; n = 25, 34.3 +/- 12.7 years; BMI = 33.2 +/- 6.8) were recruited for a double-blind, placebo controlled study. Each volunteer was randomly assigned to either the supplement (SUP; n = 25) or placebo group (PLA; n = 25). Based upon a self-reported 3-day dietary recall all volunteers were recommended a 500 kcal or 30% (maximum of 1000 kcal) reduction in caloric intake. Volunteers were also encouraged to exercise 30 minutes per day, three times per week. Results: Subjects in SUP were significantly more compliant (x(2) = 3.86, p = 0.049) in maintaining a low caloric diet at week 4, but this was not able to be maintained through the 8-week study. In addition, a significant difference in mood, feelings of fatigue and confusion were noted between the groups at week 4, but again not maintained by week 8 where only feelings of tension were improved. No differences between groups (p > 0.05) were observed for body mass, body composition, feelings of hunger, and binge eating after eight weeks. Conclusion: Supplementing with a combination of 120 mg of NOPE and 105 mg of EGCG does appear to enhance compliance to a low caloric diet and improve mood for 4-weeks, but loses its effectiveness by week 8.

Journal Title

Lipids in Health and Disease

Volume

11

Publication Date

1-1-2012

Document Type

Article

Language

English

First Page

8

WOS Identifier

WOS:000310795000001

ISSN

1476-511X

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