Therapeutic effect of hyperbaric oxygen on inclusion body myositis

    Authors

    M. Pell; P. Saththasivam; P. L. Stephens;G. Mychaskiw

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    Abbreviated Journal Title

    Undersea Hyperb. Med.

    Keywords

    ENDOPLASMIC-RETICULUM STRESS; PROTEASOME INHIBITION; MUSCLE-FIBERS; PILOT TRIAL; TNF-ALPHA; MACROPHAGES; SECRETION; AUTOPHAGY; EXPOSURE; DISEASE; Marine & Freshwater Biology; Medicine, Research & Experimental

    Abstract

    An inflammatory myopathy, inclusion body myositis (IBM) presents with progressive muscle weakness against a background of elevated creatine kinase and diffuse endomysial damage. Typically occurring in patients greater than 50 years of age, it is commonly misdiagnosed as polymyositis or other rheumatological disease and is often ineffectively treated with steroids [1]. The approach to IBM is frequently a clinical challenge due to its unique and often aberrant response to common treatment modalities. Here we report an apparent improvement in the clinical course of and associated laboratory findings in a patient with co-existing IBM following the use of hyperbaric oxygen therapy as an adjunct for managing ischemic colitis.

    Journal Title

    Undersea and Hyperbaric Medicine

    Volume

    39

    Issue/Number

    6

    Publication Date

    1-1-2012

    Document Type

    Article

    Language

    English

    First Page

    1111

    Last Page

    1114

    WOS Identifier

    WOS:000326826100008

    ISSN

    1066-2936

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