Emerging nanotechnology-based strategies for the identification of microbial pathogenesis

    Authors

    C. Kaittanis; S. Santra;J. M. Perez

    Comments

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    Abbreviated Journal Title

    Adv. Drug Deliv. Rev.

    Keywords

    Pathogen detection; Deployable sensors; Toxin detection; Bacterial drug; resistance; Nanosensors; Nanodiagnostics; ESCHERICHIA-COLI O157-H7; STAPHYLOCOCCAL-ENTEROTOXIN-B; SHIGA-LIKE; TOXIN; GOLD NANOPARTICLES; RAPID DETECTION; BACILLUS-ANTHRACIS; QUANTUM; DOTS; MAGNETIC-RELAXATION; FLOW-CYTOMETRY; ANTIMICROBIAL SUSCEPTIBILITY; Pharmacology & Pharmacy

    Abstract

    Infectious diseases are still a major healthcare problem. From food intoxication and contaminated water, to hospital-acquired diseases and pandemics, infectious agents cause disease throughout the world. Despite advancements in pathogens' identification, some of the gold-standard diagnostic methods have limitations, including laborious sample preparation, bulky instrumentation and slow data readout. In addition, new field-deployable diagnostic modalities are urgently needed in first responder and point-of-care applications. Apart from compact, these sensors must be sensitive, specific, robust and fast, in order to facilitate detection of the pathogen even in remote rural areas. Considering these characteristics, researchers have utilized innovative approaches by employing the unique properties of nanomaterials in order to achieve detection of infectious agents, even in complex media like blood. From gold nanoparticles and their plasmonic shifts to iron oxide nanoparticles and changes in magnetic properties, detection of pathogens, toxins, antigens and nucleic acids has been achieved with impressive detection thresholds. Additionally, as bacteria become resistant to antibiotics, nanotechnology has achieved the rapid determination of bacterial drug susceptibility and resistance using novel methods, such as amperometry and magnetic relaxation. Overall, these promising results hint to the adoption of nanotechnology-based diagnostics for the diagnosis of infectious diseases in diverse settings throughout the globe, preventing epidemics and safeguarding human and economic wellness. (C) 2009 Elsevier B.V. All rights reserved.

    Journal Title

    Advanced Drug Delivery Reviews

    Volume

    62

    Issue/Number

    4-5

    Publication Date

    1-1-2010

    Document Type

    Review

    Language

    English

    First Page

    408

    Last Page

    423

    WOS Identifier

    WOS:000276123400004

    ISSN

    0169-409X

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