Title
Redox-active radical scavenging nanomaterials
Abbreviated Journal Title
Chem. Soc. Rev.
Keywords
CERIUM OXIDE NANOPARTICLES; RARE-EARTH-ELEMENTS; DISMUTASE MIMETIC; PROPERTIES; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; OXYGEN VACANCIES; NITRIC-OXIDE; GLUTATHIONE-PEROXIDASE; NANOCRYSTALLINE; CERIA; Chemistry, Multidisciplinary
Abstract
Reactive oxygen and nitrogen species play a critical role in many degenerative diseases and in aging. Nanomaterials, especially modified fullerenes and cerium oxide nanoparticles, have been shown to effectively protect mammalian cells against damage caused by increased reactive oxygen or nitrogen species, likely through their direct reaction with superoxide radical, since each of these materials has been shown to act as effective superoxide dismutase mimetics in vitro. This critical review discusses the chemistry of these nanomaterials and the context in which their radical scavenging activities have been studied in biological model systems. Current studies are focused on determining the uptake, metabolism, distribution, toxicity and fate of these nanomaterials in cell and animal model systems. Ultimately if shown to be safe, these nanomaterials have the potential to be used to reduce the damaging effects of radicals in biological systems (101 references).
Journal Title
Chemical Society Reviews
Volume
39
Issue/Number
11
Publication Date
1-1-2010
Document Type
Review
DOI Link
Language
English
First Page
4422
Last Page
4432
WOS Identifier
ISSN
0306-0012
Recommended Citation
"Redox-active radical scavenging nanomaterials" (2010). Faculty Bibliography 2010s. 335.
https://stars.library.ucf.edu/facultybib2010/335
Comments
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