Redox-active radical scavenging nanomaterials

    Authors

    A. Karakoti; S. Singh; J. M. Dowding; S. Seal;W. T. Self

    Comments

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    Abbreviated Journal Title

    Chem. Soc. Rev.

    Keywords

    CERIUM OXIDE NANOPARTICLES; RARE-EARTH-ELEMENTS; DISMUTASE MIMETIC; PROPERTIES; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; OXYGEN VACANCIES; NITRIC-OXIDE; GLUTATHIONE-PEROXIDASE; NANOCRYSTALLINE; CERIA; Chemistry, Multidisciplinary

    Abstract

    Reactive oxygen and nitrogen species play a critical role in many degenerative diseases and in aging. Nanomaterials, especially modified fullerenes and cerium oxide nanoparticles, have been shown to effectively protect mammalian cells against damage caused by increased reactive oxygen or nitrogen species, likely through their direct reaction with superoxide radical, since each of these materials has been shown to act as effective superoxide dismutase mimetics in vitro. This critical review discusses the chemistry of these nanomaterials and the context in which their radical scavenging activities have been studied in biological model systems. Current studies are focused on determining the uptake, metabolism, distribution, toxicity and fate of these nanomaterials in cell and animal model systems. Ultimately if shown to be safe, these nanomaterials have the potential to be used to reduce the damaging effects of radicals in biological systems (101 references).

    Journal Title

    Chemical Society Reviews

    Volume

    39

    Issue/Number

    11

    Publication Date

    1-1-2010

    Document Type

    Review

    Language

    English

    First Page

    4422

    Last Page

    4432

    WOS Identifier

    WOS:000283141300028

    ISSN

    0306-0012

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