Leptin and leptin receptor genetic variants associate with habitual physical activity and the arm body composition response to resistance training

    Authors

    S. Walsh; C. J. Haddad; M. A. Kostek; T. J. Angelopoulos; P. M. Clarkson; P. M. Gordon; N. M. Moyna; P. S. Visich; R. F. Zoeller; R. L. Seip; S. Bilbie; P. D. Thompson; J. Devaney; H. Gordish-Dressman; E. P. Hoffman; T. B. Price;L. S. Pescatello

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    Abbreviated Journal Title

    Gene

    Keywords

    Exercise; Genomics; Polymorphism; OF-SPORTS-MEDICINE; PUBLIC-HEALTH; QUEBEC FAMILY; PIMA-INDIANS; FOOD-INTAKE; POLYMORPHISM; MUSCLE; RECOMMENDATION; STRENGTH; EXERCISE; Genetics & Heredity

    Abstract

    Purpose: We investigated the influence of Leptin (LEP) and leptin receptor (LEPR) SNPs on habitual physical activity (PA) and body composition response to a unilateral, upper body resistance training (RI) program. Methods: European-derived American volunteers (men=111, women = 131, 23.4+/-5.4 yr, 24.4+/-4.6 kg.m(-2)) were genotyped for LEP 19 G > A (rs2167270), and LEPR 326 A > G (rs1137100), 668 A > G (rs1137101), 3057 G > A (rs1805096), and 1968 G > C (rs8179183). They completed the Paffenbarger PA Questionnaire. Arm muscle and subcutaneous fat volumes were measured before and after 12 wk of supervised RI with MRI. Multivariate and repeated measures ANCOVA tested differences among phenotypes by genotype and gender with age and body mass index as covariates. Results: Adults with the LEP 19 GG genotype reported more kcaI/wk in vigorous intensity PA (1273.3+/-176.8, p = 0.017) and sports/recreation (1922.8+/-226.0, p < 0.04) than A allele carriers (718.0+/-147.2, 1328.6+/-188.2, respectively). Those with the LEP 19 GG genotype spent more h/wk in light intensity PA (39.7+/-1.6) than A allele carriers (35.0+/-1.4, p = 0.03). In response to RI, adults with the LEPR 668 G allele gained greater arm muscle volume (67,687.05+/-3186.7 vs. 52,321.87+/-5125.05 mm(3), p=0.01) and subcutaneous fat volume (10,599.89+/-3683.57 vs. -5224.73+/-5923.98 mm(3), p=0.02) than adults with the LEPR 668 AA genotype, respectively. Conclusion: LEP19 G > A and LEPR 668 A > G associated with habitual PA and the body composition response to RT. These LEP and LEPR SNPs are located in coding exons likely influencing LEP and LEPR function. Further investigation is needed to confirm our findings and establish mechanisms for LEP and LEPR genotype and PA and body composition associations we observed. (C) 2012 Elsevier B.V. All rights reserved.

    Journal Title

    Gene

    Volume

    510

    Issue/Number

    1

    Publication Date

    1-1-2012

    Document Type

    Article

    Language

    English

    First Page

    66

    Last Page

    70

    WOS Identifier

    WOS:000313611700009

    ISSN

    0378-1119

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