Update on clinical trials for the prevention of acute kidney injury in patients undergoing cardiac surgery

    Authors

    M. M. Alsabbagh; A. Asmar; N. I. Ejaz; R. K. Aiyer; G. Kambhampati;A. A. Ejaz

    Comments

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    Abbreviated Journal Title

    Am. J. Surg.

    Keywords

    Acute kidney injury; Clinical trials; Cardiac surgery; Diagnosis; Prevention; Treatment; ACUTE-RENAL-FAILURE; RANDOMIZED CONTROLLED-TRIAL; HIGH-RISK PATIENTS; INTRAAORTIC BALLOON PUMP; CRITICALLY-ILL PATIENTS; ARTERY-BYPASS; SURGERY; LEFT-VENTRICULAR DYSFUNCTION; POST-CARDIOPULMONARY BYPASS; ALL-CAUSE MORTALITY; OFF-PUMP; Surgery

    Abstract

    BACKGROUND: Effective therapeutic agents for the prevention and treatment of acute kidney injury (AKI) after cardiac surgery remain elusive despite the tremendous advances in surgical techniques, technology, and understanding of disease processes. Recent developments and their effect on the incidence of AKI after cardiac surgery are discussed. DATA SOURCES: Published clinical trials in PubMed, strength of evidence assessed by the guidelines of the American Family Physicians. CONCLUSIONS: The definition of AKI has changed, and the focus of interventions has shifted from treatment to prevention to recovery from AKI. Antioxidants and biological agents have been added to classic armaments of hydration and diuretics in addition to tighter metabolic control to prevent AKI. Although the treatment options remain unsatisfactory, a lot of progress nevertheless continues to be made in the prevention and treatment of AKI. (C) 2013 Elsevier Inc. All rights reserved.

    Journal Title

    American Journal of Surgery

    Volume

    206

    Issue/Number

    1

    Publication Date

    1-1-2013

    Document Type

    Review

    Language

    English

    First Page

    86

    Last Page

    95

    WOS Identifier

    WOS:000321510100014

    ISSN

    0002-9610

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