Title
Optical Detection of Lithocholic Acid with Liquid Crystal Emulsions
Abbreviated Journal Title
Langmuir
Keywords
CANCER CELL-LINES; BILE-ACIDS; MASS-SPECTROMETRY; BIOLOGICAL-FLUIDS; INDUCED APOPTOSIS; DROPLETS; MONOLAYERS; TRANSITIONS; SENSORS; Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science, ; Multidisciplinary
Abstract
The concentration level of bile acids is a clinical biomarker for the diagnosis of intestinal diseases because individuals suffering from intestinal diseases have a sharply increased concentration of bile acids at micromolar levels. Here, we report the detection of lithocholic acid (LCA) in aqueous solution by using surfactant-stabilized 4-n-pentyl-4'-cyanobiphenyl (5CB) liquid crystal droplets as an optical probe. We find that the surfactant adsorbed at the 5CB/water interface can be replaced by LCA, triggering a radial-to-bipolar configuration transition of the 5CB in the droplets. By simply observing the LCA-triggered transition with a polarizing optical microscope, micromolar levels of LCA in aqueous solution can be detected. The detection limit and selectivity of surfactant-stabilized 5CB droplets for LCA depend on the chain length and headgroup of the surfactants used for stabilizing 5CB droplets.
Journal Title
Langmuir
Volume
29
Issue/Number
1
Publication Date
1-1-2013
Document Type
Article
DOI Link
Language
English
First Page
387
Last Page
392
WOS Identifier
ISSN
0743-7463
Recommended Citation
"Optical Detection of Lithocholic Acid with Liquid Crystal Emulsions" (2013). Faculty Bibliography 2010s. 3700.
https://stars.library.ucf.edu/facultybib2010/3700
Comments
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