Mitigation of endometriosis using regenerative cerium oxide nanoparticles

    Authors

    K. Chaudhury; K. N. Babu; A. K. Singh; S. Das; A. Kumar;S. Seal

    Comments

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    Abbreviated Journal Title

    Nanomed.-Nanotechnol. Biol. Med.

    Keywords

    Cerium oxide nanoparticles; Antioxidant; Endometriosis; Anti-angiogenesis; LIVING HUMAN OOCYTES; OXIDATIVE-STRESS; MEIOTIC SPINDLE; MOUSE MODEL; ANTIOXIDANT; POLSCOPE; WOMEN; CARDIOMYOPATHY; VISUALIZATION; ANGIOGENESIS; Nanoscience & Nanotechnology; Medicine, Research & Experimental

    Abstract

    Cerium oxide nanoparticles (nanoceria) have recently received attention from the scientific community due to their unique free radicals (specially superoxide radical and hydrogen peroxide) scavenging property in biological system, both in vitro and in vivo. It is suggested that free radicals play an important role in the pathogenesis of endometriosis. In this study we have shown that nanoceria mitigate the endometrial lesions induced in mice model by decreasing oxidative stress and inhibiting angiogenesis. Moreover, nanoceria were also observed to protect endometriosis-related adverse effects on the oocytes, which is critical for successful pregnancy. Summarizing, nanoceria have shown promising efficacy against endometriosis related pathogenesis. From the Clinical Editor: Free radicals have been implemented in the pathogenesis of endometriosis. In a murine model the authors demonstrated successful treatment of endometriosis with nanoceria, and protection of endometriosis-related adverse effects on the oocytes, paving the way to potential clinical translational applications in the future. (C) 2013 Elsevier Inc. All rights reserved.

    Journal Title

    Nanomedicine-Nanotechnology Biology and Medicine

    Volume

    9

    Issue/Number

    3

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    439

    Last Page

    448

    WOS Identifier

    WOS:000316728800014

    ISSN

    1549-9634

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