Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing

    Authors

    S. Chigurupati; M. R. Mughal; E. Okun; S. Das; A. Kumar; M. McCaffery; S. Seal;M. P. Mattson

    Comments

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    Abbreviated Journal Title

    Biomaterials

    Keywords

    Cerium oxide nanoparticles; Vascular endothelial cells; Keratinocytes; Fibroblasts; Wound healing; Oxidative stress; TUBBY MICE; NANOCERIA; ANTIOXIDANT; ANGIOGENESIS; DEGENERATION; MODULATION; PROTECTION; PROTEINS; REPAIR; Engineering, Biomedical; Materials Science, Biomaterials

    Abstract

    Rapid and effective wound healing requires a coordinated cellular response involving fibroblasts, keratinocytes and vascular endothelial cells (VECs). Impaired wound healing can result in multiple adverse health outcomes and, although antibiotics can forestall infection, treatments that accelerate wound healing are lacking. We now report that topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs. The Nanoceria penetrated into the wound tissue and reduced oxidative damage to cellular membranes and proteins, suggesting a therapeutic potential for topical treatment of wounds with antioxidant nanoparticles. Published by Elsevier Ltd.

    Journal Title

    Biomaterials

    Volume

    34

    Issue/Number

    9

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    2194

    Last Page

    2201

    WOS Identifier

    WOS:000315179200005

    ISSN

    0142-9612

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