Cerium oxide nanoparticles: applications and prospects in nanomedicine
Abbreviated Journal Title
Nanomedicine
Keywords
antioxidant therapy; catalytic antioxidant nanoparticle; cerium oxide; nanoparticle; neurodegeneration; oxidative stress; pH-sensitive; nanoparticle; regenerative medicine; OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; CEO2 NANOPARTICLES; LIPID-PEROXIDATION; NEURONAL SURVIVAL; EPITHELIAL-CELLS; REDOX STATE; TUBBY MICE; LIFE-SPAN; IN-VITRO; Biotechnology & Applied Microbiology; Nanoscience & Nanotechnology
Abstract
Promising results have been obtained using cerium (Ce) oxide nanoparticles (CNPs) as antioxidants in biological systems. CNPs have unique regenerative properties owing to their low reduction potential and the coexistence of both Ce3+/Ce4+ on their surfaces. Defects in the crystal lattice due to the presence of Ce3+ play an important role in tuning the redox activity of CNPs. The surface Ce3+:Ce4+ ratio is influenced by the microenvironment. Therefore, the microenvironment and synthesis method adopted also plays an important role in determining the biological activity and toxicity of CNPs. The presence of a mixed valance state plays an important role in scavenging reactive oxygen and nitrogen species. CNPs are found to be effective against pathologies associated with chronic oxidative stress and inflammation. CNPs are well tolerated in both in vitro and in vivo biological models, which makes CNPs well suited for applications in nanobiology and regenerative medicine.
Journal Title
Nanomedicine
Volume
8
Issue/Number
9
Publication Date
1-1-2013
Document Type
Review; Book Chapter
DOI Link
Language
English
First Page
1483
Last Page
1508
WOS Identifier
ISSN
1743-5889
Recommended Citation
"Cerium oxide nanoparticles: applications and prospects in nanomedicine" (2013). Faculty Bibliography 2010s. 3857.
https://stars.library.ucf.edu/facultybib2010/3857
Comments
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