Decreased Levels of Proapoptotic Factors and Increased Key Regulators of Mitochondrial Biogenesis Constitute New Potential Beneficial Features of Long-lived Growth Hormone Receptor GeneDisrupted Mice

    Authors

    A. Gesing; M. M. Masternak; A. Lewinski; M. Karbownik-Lewinska; J. J. Kopchick;A. Bartke

    Comments

    Authors: contact us about adding a copy of your work at STARS@ucf.edu

    Abbreviated Journal Title

    J. Gerontol. Ser. A-Biol. Sci. Med. Sci.

    Keywords

    Aging; Longevity; Dwarf mice; Apoptosis; Mitochondrial biogenesis; GHRKO; mice; Calorie restriction; Visceral fat removal; ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE; GENE-DISRUPTED MICE; POLYCYSTIC KIDNEY-DISEASE; NECROSIS-FACTOR-ALPHA; BCL-2 FAMILY-MEMBERS; KNOCKOUT GHRKO MICE; CALORIE RESTRICTION; LIFE-SPAN; SKELETAL-MUSCLE; Geriatrics & Gerontology; Gerontology

    Abstract

    Decreased somatotrophic signaling is among the most important mechanisms associated with extended longevity. Mice homozygous for the targeted disruption of the growth hormone (GH) receptor gene (GH receptor knockout; GHRKO) are obese and dwarf, are characterized by a reduced weight and body size, undetectable levels of GH receptor, high concentration of serum GH, and greatly reduced plasma levels of insulin and insulin-like growth factor-I, and are remarkably long lived. Recent results suggest new features of GHRKO mice that may positively affect longevityudecreased levels of proapoptotic factors and increased levels of key regulators of mitochondrial biogenesis. The alterations in levels of the proapoptotic factors and key regulators of mitochondrial biogenesis were not further improved by two other potential life-extending interventionsucalorie restriction and visceral fat removal. This may attribute the primary role to GH resistance in the regulation of apoptosis and mitochondrial biogenesis in GHRKO mice in terms of increased life span.

    Journal Title

    Journals of Gerontology Series a-Biological Sciences and Medical Sciences

    Volume

    68

    Issue/Number

    6

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    639

    Last Page

    651

    WOS Identifier

    WOS:000319466000002

    ISSN

    1079-5006

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