Antiviral Activity of Retrocyclin RC-101, a Candidate Microbicide Against Cell-Associated HIV-1

    Authors

    P. Gupta; C. Lackman-Smith; B. Snyder; D. Ratner; L. C. Rohan; D. Patton; B. Ramratnam;A. M. Cole

    Comments

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    Abbreviated Journal Title

    Aids Res. Hum. Retrovir.

    Keywords

    VAGINAL MICROBICIDE; ANAL SEX; INFECTION; SEMEN; TRANSMISSION; MEN; PREVENTION; INHIBITORS; TENOFOVIR; MACAQUES; Immunology; Infectious Diseases; Virology

    Abstract

    Microbicides have been evaluated mostly against cell-free HIV-1. Because semen contains both cell-free and cell-associated HIV-1, HIV-1 transmission could occur via either or both sources. Therefore, it is important to examine the antiviral activity of microbicides against cell-associated HIV-1. The cyclic antimicrobial peptide retrocyclin RC-101 has been shown previously to have antiviral activity against cell-free HIV-1, with no associated cellular toxicity. In this article we have examined the antiviral activity of RC-101 against cell-associated HIV-1. The results demonstrate potent antiviral activity of RC-101 against cell-cell HIV-1 transmission in both CD4-dependent and CD4-independent assays against CCR5- and CXCR4-tropic HIV-1, with no cellular toxicity. Furthermore, this antiviral activity was retained in the presence of human seminal plasma. The potent antiviral activity of RC-101 against cell-associated HIV-1 reported here, and the previously reported antiviral activity in cervical tissues, suggest that RC-101 is an excellent and promising microbicide candidate against HIV-1.

    Journal Title

    Aids Research and Human Retroviruses

    Volume

    29

    Issue/Number

    2

    Publication Date

    1-1-2013

    Document Type

    Article

    Language

    English

    First Page

    391

    Last Page

    396

    WOS Identifier

    WOS:000313810100027

    ISSN

    0889-2229

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