Solid-State NMR Characterization of the Molecular Conformation in Disordered Methyl alpha-L-Rhamnofuranoside
Abbreviated Journal Title
J. Phys. Chem. A
Keywords
CHEMICAL-SHIFT TENSORS; ZEOLITE CRYSTAL-STRUCTURES; POWDER DIFFRACTION; DATA; X-RAY-DIFFRACTION; STRUCTURAL-CHARACTERIZATION; MICROCRYSTALLINE; SOLIDS; STRUCTURE REFINEMENT; CORRELATION-ENERGY; AMBUIC ACID; UNIT-CELL; Chemistry, Physical; Physics, Atomic, Molecular & Chemical
Abstract
A combination of solid-state C-13 NMR tensor data and DFT computational methods is utilized to predict the conformation in disordered methyl alpha-L-rhamnofuranoside. This previously uncharacterized solid is found to be crystalline and consists of at least six distinct conformations that exchange on the kHz time scale. A total of 66 model structures were evaluated, and six were identified as being consistent with experimental C-13 NMR data. All feasible structures have very similar carbon and oxygen positions and differ most significantly in OH hydrogen orientations. A concerted rearrangement of OH hydrogens is proposed to account for the observed dynamic disorder. This rearrangement is accompanied by smaller changes in ring conformation and is slow enough to be observed on the NMR time scale due to severe steric crowding among ring substituents. The relatively minor differences in non-hydrogen atom positions in the final structures suggest that characterization of a complete crystal structure by X-ray powder diffraction may be feasible.
Journal Title
Journal of Physical Chemistry A
Volume
117
Issue/Number
26
Publication Date
1-1-2013
Document Type
Article
DOI Link
Language
English
First Page
5534
Last Page
5541
WOS Identifier
ISSN
1089-5639
Recommended Citation
"Solid-State NMR Characterization of the Molecular Conformation in Disordered Methyl alpha-L-Rhamnofuranoside" (2013). Faculty Bibliography 2010s. 4085.
https://stars.library.ucf.edu/facultybib2010/4085
Comments
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