Title
Liquid crystal based sensors for the detection of cholic acid
Abbreviated Journal Title
Anal. Methods
Keywords
BILE-ACIDS; MASS-SPECTROMETRY; BIOLOGICAL-FLUIDS; MONOLAYERS; INTERFACE; SURFACES; SERUM; Chemistry, Analytical; Food Science & Technology; Spectroscopy
Abstract
The concentration level of cholic acid is a biomarker for the early diagnosis of liver and intestinal diseases. We present a biosensor platform based on the anchoring transition of 4-cyano-4'-pentylbiphenyl (5CB) liquid crystals at surfactant-laden 5CB/aqueous interfaces for the detection of cholic acid (CA) in aqueous solution. In the biosensor platform, the competitive adsorption of CA at the surfactant-laden 5CB/aqueous interfaces can trigger a homeotropic-to-planar anchoring transition of the 5CB at the interface, which can be easily observed using a polarizing optical microscope. We find that the detection limit of the 5CB based biosensors for CA depends on the pH and ionic strength of the aqueous phase and the headgroup of the surfactants.
Journal Title
Analytical Methods
Volume
5
Issue/Number
16
Publication Date
1-1-2013
Document Type
Article
DOI Link
Language
English
First Page
4126
Last Page
4130
WOS Identifier
ISSN
1759-9660
Recommended Citation
"Liquid crystal based sensors for the detection of cholic acid" (2013). Faculty Bibliography 2010s. 4096.
https://stars.library.ucf.edu/facultybib2010/4096
Comments
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