Abbreviated Journal Title
Antimicrob. Agents Chemother.
Keywords
ANTIMALARIAL-DRUG DISCOVERY; TRANSPORT-SYSTEM; PREDICTION; SOLUBILITY; ANALOGS; Microbiology; Pharmacology & Pharmacy
Abstract
Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC(50)s) in the nM to mu M range. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.
Journal Title
Antimicrobial Agents and Chemotherapy
Volume
57
Issue/Number
6
Publication Date
1-1-2013
Document Type
Article
Language
English
First Page
2874
Last Page
2877
WOS Identifier
ISSN
0066-4804
Recommended Citation
Niemand, Jandeli; Burger, Pieter; Verlinden, Bianca K.; Reader, Janette; Joubert, Annie M.; Kaiser, Annette; Louw, Abraham I.; Kirk, Kiaran; Phanstiel, Otto IV; and Birkholtz, Lyn-Marie, "Anthracene-Polyamine Conjugates Inhibit In Vitro Proliferation of Intraerythrocytic Plasmodium falciparum Parasites" (2013). Faculty Bibliography 2010s. 4473.
https://stars.library.ucf.edu/facultybib2010/4473
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