Authors

J. Niemand; P. Burger; B. K. Verlinden; J. Reader; A. M. Joubert; A. Kaiser; A. I. Louw; K. Kirk; O. Phanstiel;L. M. Birkholtz

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Abbreviated Journal Title

Antimicrob. Agents Chemother.

Keywords

ANTIMALARIAL-DRUG DISCOVERY; TRANSPORT-SYSTEM; PREDICTION; SOLUBILITY; ANALOGS; Microbiology; Pharmacology & Pharmacy

Abstract

Anthracene-polyamine conjugates inhibit the in vitro proliferation of the intraerythrocytic human malaria parasite Plasmodium falciparum, with 50% inhibitory concentrations (IC(50)s) in the nM to mu M range. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.

Journal Title

Antimicrobial Agents and Chemotherapy

Volume

57

Issue/Number

6

Publication Date

1-1-2013

Document Type

Article

Language

English

First Page

2874

Last Page

2877

WOS Identifier

WOS:000319272100062

ISSN

0066-4804

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