Abbreviated Journal Title
Appl. Phys. Lett.
Keywords
CROSS-SECTIONAL AREA; STRENGTH; BIOSENSORS; Physics, Applied
Abstract
Rigorous analysis of muscle function in in vitro systems is needed for both acute and chronic biomedical applications. Forces generated by skeletal myotubes on bio-microelectromechanical cantilevers were calculated using a modified version of Stoney's thin-film equation and finite element analysis (FEA), then analyzed for regression to physical parameters. The Stoney's equation results closely matched the more intensive FEA and the force correlated to cross-sectional area (CSA). Normalizing force to measured CSA significantly improved the statistical sensitivity and now allows for close comparison of in vitro data to in vivo measurements for applications in exercise physiology, robotics, and modeling neuromuscular diseases.
Journal Title
Applied Physics Letters
Volume
103
Issue/Number
8
Publication Date
1-1-2013
Document Type
Article
DOI Link
Language
English
First Page
5
WOS Identifier
ISSN
0003-6951
Recommended Citation
Pirozzi, K. L.; Long, C. J.; McAleer, C. W.; Smith, A. S. T.; and Hickman, J. J., "Correlation of embryonic skeletal muscle myotube physical characteristics with contractile force generation on an atomic force microscope-based bio-microelectromechanical systems device" (2013). Faculty Bibliography 2010s. 4538.
https://stars.library.ucf.edu/facultybib2010/4538
Comments
Authors: contact us about adding a copy of your work at STARS@ucf.edu
"This article may be downloaded for personal use only. Any other use requires prior permission of the author and AIP Publishing. This article appeared in the linked citation and may be found originally at Applied Physics Letters."